AI Article Synopsis
- - Rural southwest Alaska faced significant impacts from COVID-19, prompting an analysis of vaccine effectiveness (VE) data from the local health system during 2021.
- - The research found that the VE against symptomatic SARS-CoV-2 infection varied over time, with the primary vaccine series showing 91.3% effectiveness at peak, but dropping to 37% by the end of the year; however, a booster dose significantly restored protection at 92.1%.
- - Overall, the study underscored that COVID-19 vaccination provided strong protection against hospitalization, with a cumulative VE of 91.9% throughout the study period.
Article Abstract
The population in rural southwest Alaska has been disproportionately affected by COVID-19. To assess the benefit of COVID-19 vaccines, we analyzed data from the regional health system. We estimated vaccine effectiveness (VE) during January 16-December 3, 2021, against symptomatic SARS-CoV-2 infection after a primary series or booster dose, and overall VE against hospitalization. VE of a primary series against symptomatic infection among adult residents was 91.3% (95% CI: 85.7, 95.2) during January 16-May 7, 2021, 50.3% (95% CI, 41.1%-58.8%) during July 17-September 24, and 37.0% (95% CI, 27.8-45.0) during September 25-December 3, 2021; VE of a booster dose during September 25-December 3, 2021, was 92.1% (95% CI: 87.2-95.2). During the overall study period, VE against hospitalization was 91.9% (95% CI: 85.4-95.5). COVID-19 vaccination offered strong protection against hospitalization and a booster dose restored protection against symptomatic infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150184 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2023.04.070 | DOI Listing |
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