AI Article Synopsis
- The study compares the effectiveness of two serological screening tests, Alinity i rHTLV-I/II and LIAISON® XL murex recHTLV-I/II, against the ARCHITECT rHTLVI/II test for diagnosing HTLV-I and II infections.
- It involved analyzing 119 serum samples from known HTLV-I patients and 184 from uninfected individuals to evaluate the tests' performance.
- Results showed that both Alinity i and LIAISON® tests had total agreement with the ARCHITECT reference test, making them reliable options for HTLV screening.
Article Abstract
Background: Diagnosis of Human T-cell Lymphotropic Virus (HTLV) types I and II infection requires sequencial testing with firstly a screening using an Enzyme immunoassay followed by a confirmatory test.
Objectives: To compare the performances of the Alinity i rHTLV-I/II (Abbott®) and LIAISON® XL murex recHTLV-I/II serological screening tests to the ARCHITECT rHTLVI/II test followed if positive by HTLV BLOT 2.4, MP Diagnostics as the reference.
Study Design: 119 serum samples from 92 known HTLV-I infected patients and 184 from uninfected patients with HTLV were analyzed in parallel with, Alinity i rHTLV-I/II, LIAISON® XL murex recHTLV-I/II and ARCHITECT rHTLVI/II.
Results: Alinity i rHTLV-I/II and LIAISON® XL murex recHTLV-I/II exhibited a total agreement with ARCHITECT rHTLVI/II for both positive and negative samples. Both tests are suitable alternatives for HTLV screening.
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| http://dx.doi.org/10.1016/j.jcv.2023.105446 | DOI Listing |
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Article Synopsis
- The study compares the effectiveness of two serological screening tests, Alinity i rHTLV-I/II and LIAISON® XL murex recHTLV-I/II, against the ARCHITECT rHTLVI/II test for diagnosing HTLV-I and II infections.
- It involved analyzing 119 serum samples from known HTLV-I patients and 184 from uninfected individuals to evaluate the tests' performance.
- Results showed that both Alinity i and LIAISON® tests had total agreement with the ARCHITECT reference test, making them reliable options for HTLV screening.
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