In an effort to exploit the natural antifungal pogostone, its simplified scaffold dehydroacetic acid (DHA) was used as a lead compound to semi-synthesize 56 DHA derivatives (I1-48, II, III, and IV1-6). Among them, compound IV4 exhibited the most potent antifungal activity with 11.0 μM EC against mycelial growth of Sclerotinia sclerotiorum (Lib.) de Bary whose sclerotia production was also completely suppressed at this concentration. Furthermore, IV4 could completely inhibit infection cushion formation of S. sclerotiorum on rape leaves and achieved a preventive efficacy of 90.2 % at 500 μM, which was on the same level as that of commercial boscalid at 30 μM (88.7 %). The results of physiological and ultrastructural studies indicated that IV4 might disrupt the cell membrane permeability or induce the imbalance of mitochondrial membrane potential homeostasis to exert the antifungal mode of action. Besides, the robust and predicative three-dimensional quantitative structure-activity relationship (3D-QSAR) models were developed and discussed herein.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.202300128 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structure and Fungicidal Activity of Secondary Metabolites Isolated from b-3.
J Fungi (Basel)
October 2024
State Key Laboratory of Southwestern Chinese Medicine Resource, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Two new harziane diterpenes (-), five undescribed cyclonerane sesquiterpenes (-), and three known compounds, 11-cycloneren-3, 7, 10-triol (), harziandione (), and dehydroacetic acid (), were isolated from b-3. Their structures were elucidated via comprehensive inspection of spectral evidence in HRESIMS and 1D and 2D NMR, and the absolute configuration of - was confirmed by NMR, ECD calculation, as well as Mosher's method. In vitro fungicidal activity showed that some compounds showed great inhibitory activity against pathogenic fungi, including , , , and , among which compound showed 100% inhibition of and .
View Article and Find Full Text PDFCombined application of the endophyte Bacillus K1 and sodium dehydroacetate alleviates postharvest gray mold in grapes.
Food Microbiol
January 2025
Shandong Institute of Pomology, Tai'an, 271000, China.
Botrytis cinerea, which causes postharvest gray mold, is a primary pathogen that limits grape shelf-life and consumption and causes substantial yield loss worldwide. The combined use of biocontrol agents and food additives has attracted increasing interest. The effects of combined treatment with the endophyte Bacillus subtilis K1 and sodium dehydroacetate (SD) on the occurrence of gray mold and maintenance of grape fruit quality were studied.
View Article and Find Full Text PDFOptical Chemosensor as a Sensitive and Selective Tool for the Detection of Thiocyanate Ions Via Cu Induced Sensor and Its Practical Application.
J Fluoresc
September 2024
Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, 125001, Haryana, India.
Article Synopsis
- The study focuses on a new probe called DPD, designed for detecting copper (Cu) ions in methanol, utilizing specific chemical components and showing selective binding through UV-Vis measurements.
- Binding studies confirmed a 2:1 stoichiometry ratio and an impressive detection limit of 1.38×10 M for Cu ions.
- The DPD probe also demonstrated its ability to detect SCN ions with a low limit of detection and showed practical application by analyzing real water and blood samples, outperforming existing sensors in selectivity and sensitivity.
Fast Determination of Eleven Food Additives in River Water Using C18 Functionalized Magnetic Organic Polymer Nanocomposite Followed by High-Performance Liquid Chromatography.
Molecules
August 2024
College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China.
Article Synopsis
- - A novel magnetic nanomaterial, C18-PS-DVB-FeO, was created using FeO as the core and PS-DVB as the shell, providing excellent chemical stability and magnetic properties for effective extraction in environmental applications.
- - A magnetic dispersive solid phase extraction (Mag-dSPE) method was developed to analyze food additives in river water, using C18-PS-DVB-FeO as an adsorbent combined with high-performance liquid chromatography (HPLC) for precise detection.
- - The method successfully detected 11 food additives with limits of detection between 0.6-3.1 μg/L and showed high recovery rates, while the nanomaterial maintained extraction efficiency after five reuse
Sodium Dehydroacetate and Dehydroacetic Acid.
Int J Toxicol
October 2024
Cosmetic Ingredient Review Executive Director.
The Expert Panel for Cosmetic Ingredient Safety (Panel) first published a safety assessment of Sodium Dehydroacetate and Dehydroacetic Acid in 1985. The Panel previously concluded that Sodium Dehydroacetate and Dehydroacetic Acid are safe as used in the present practices of use and concentration, as stated in that report. Upon re-review in 2003, the Panel reaffirmed the original conclusion, as published in 2006.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!