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Importance: The effectiveness of different approaches to dementia care is unknown.
Objective: To determine the effectiveness of health system-based, community-based dementia care, and usual care for persons with dementia and for caregiver outcomes.
Design, Setting, And Participants: Randomized clinical trial of community-dwelling persons living with dementia and their caregivers conducted at 4 sites in the US (enrollment June 2019-January 2023; final follow-up, August 2023).
Effects of acupuncture at the Taichong (LIV3) and Hegu (LI4) points on functional connectivity with the retrosplenial cortex in patients with Alzheimer's disease.
Front Neurosci
January 2025
Department of Radiology, Aerospace Center Hospital, Beijing, China.
Background: Acupuncture has been demonstrated to have a promising effect on Alzheimer's disease (AD), but the underlying neural mechanisms remain unclear. The retrosplenial cortex (RSC) is one of the earliest brain regions affected in AD, and changes in its functional connectivity (FC) are reported to underlie disease-associated memory impairment. The aim of this study was to examine the effect of acupuncture on FC with the RSC in patients with AD.
View Article and Find Full Text PDFH*10 neutron dosimetry (unlike gamma dosimetry), requires consideration of neutron energy spectra due to the 20× variation of the weight factor over the thermal-to-fast energy range, as well as the neutron radiation field dose rates ranging from cosmic, ~.01 μSv h-1 levels to commonly encountered ~10-200 μSv h-1 in nuclear laboratories/processing plants, and upwards of 104 Sv h-1 in nuclear reactor environments. This paper discusses the outcome of the comparison of spectrum-weighted neutron dosimetry covering thermal-to-fast energy using the novel H*-TMFD spectroscopy-enabled sensor system in comparison with measurements using state-of-the-art neutron dosimetry systems at SRNS-Rotating Spectrometer (ROSPEC), and non-spectroscopic Eberline ASP2E ("Eberline") and Ludlum 42-49B ("Ludlum") survey instrumentation.
View Article and Find Full Text PDFEnzymatic hydrolysis of acyl glucuronide metabolites in human liver microsomes correlates to the risk of idiosyncratic drug toxicity.
J Pharm Sci
January 2025
Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Acyl glucuronide (AG) is a reactive metabolite that causes idiosyncratic drug toxicity (IDT). Although the instability of AG is used to predict the IDT risk of novel drug candidates, it sometimes overestimates the IDT risk. We investigated whether the rate of enzymatic AG hydrolysis in human liver microsomes (HLM) can predict the risk of IDT.
View Article and Find Full Text PDFValproate discontinuation in girls and women of childbearing age with epilepsy: An Italian multicenter retrospective study on prescribing patterns and outcomes.
Epilepsia
January 2025
IRCCS Institute of Neurological Sciences of Bologna, Full Member of the European Reference Network EpiCARE, Bologna, Italy.
Objective: This study aimed to identify prescribing behaviors in women of childbearing potential (WOCP) with epilepsy already taking valproate (VPA), and to investigate the relationship between VPA maintenance, substitution, reduction, or withdrawal as part of polytherapy, and seizure worsening or relapse.
Methods: We retrospectively reviewed the prescription behaviors and seizure outcomes in WOCP (16-50 years of age) with epilepsy, referred to eight Italian epilepsy centers, who were taking VPA for at least 1 year between 2014 and 2019.
Results: Among 750 women (~12% of all WOCP), 528 (70.
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