New fourth-generation synchrotron radiation facilities bring large gains in X-ray source brightness, but also challenges in making full use of their potentials. Some of these challenges have been faced at X-ray free-electron laser facilities.
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http://dx.doi.org/10.1107/S2052252523003585 | DOI Listing |
Drug Dev Res
February 2025
Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, India.
The remarkable clinical success of third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has significantly advanced the treatment landscape for non-small-cell lung cancer (NSCLC). However, the emergence of the tertiary point mutation C797S poses a substantial obstacle to their clinical efficacy, leading to a dearth of FDA-approved targeted therapies for patients harboring this mutation. Addressing this pressing clinical challenge necessitates the development of novel therapeutic agents targeting the clinically challenging EGFR mutation.
View Article and Find Full Text PDFLight Sci Appl
December 2024
Shenzhen Key Laboratory of Laser Engineering, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Room temperature femtowatt sensitivity remains a sought-after attribute, even among commercial inorganic infrared (IR) photodetectors (PDs). While organic IR PDs are poised to emerge as a pivotal sensor technology in the forthcoming Fourth-Generation Industrial Era, their performance lags behind that of their inorganic counterparts. This discrepancy primarily stems from poor external quantum efficiencies (EQE), driven by inadequate exciton dissociation (high exciton binding energy) within organic IR materials, exacerbated by pronounced non-radiative recombination at narrow bandgaps.
View Article and Find Full Text PDFLuminescence
November 2024
Department of Physics, Georgia Southern University, Statesboro, Georgia, USA.
Rev Sci Instrum
October 2024
Department of Physics, Technical University of Dortmund, Otto-Hahn-Straße 4, 44227 Dortmund, Germany.
In this paper, we demonstrate the successful implementation of reconfigurable field-programmable gate array technology into a pulse-resolved data acquisition system to achieve a femtosecond temporal resolution in ultrafast pump-probe experiments in real-time at large scale facilities. As proof of concept, electro-optic sampling of terahertz waveforms radiated by a superradiant emitter of a quasi-cw accelerator operating at a 50 kHz repetition rate and probed by an external laser system is performed. Options for up-scaling the developed technique to a MHz range of repetition rates are discussed.
View Article and Find Full Text PDFPLoS One
September 2024
School of Physical Education, Hainan Normal University, Haikou, China.
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