The human skin is populated by a diverse pool of memory T cells, which can act rapidly in response to pathogens and cancer antigens. Tissue-resident memory T cells (T ) have been implicated in range of allergic, autoimmune and inflammatory skin diseases. Clonal expansion of cells with T properties is also known to contribute to cutaneous T-cell lymphoma. Here, we review the heterogeneous phenotypes, transcriptional programs, and effector functions of skin T . We summarize recent studies on T formation, longevity, plasticity, and retrograde migration and contextualize the findings to skin T and their role in maintaining skin homeostasis and altered functions in skin disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10952320 | PMC |
| http://dx.doi.org/10.1111/imr.13213 | DOI Listing |
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