AI Article Synopsis
- 4-aryl-4H-chromenes have gained interest as possible anticancer agents, leading to the design of new methoxy-substituted compounds for better effectiveness.
- The newly synthesized compounds were tested on two types of human cancer cell lines (MCF-7 and PC3) and one normal cell line, exploring their ability to induce apoptosis through various analytical methods.
- The results indicated that compound 5g, with specific methoxy groups, showed the strongest anticancer activity against the PC3 cell line and effectively induced apoptosis, suggesting its potential as a cancer treatment option.
Article Abstract
Background/introduction: 4-aryl-4H-chromenes have attracted attention as potential anticancer agents.
Objective: In an effort to discover effective compounds, we designed a new series of these chromenes with methoxy substitution at 2, 3, 4, 5, and 6 positions.
Methods: The synthesized compounds were tested for anticancer properties against two human cancer cell lines (MCF- 7 and PC3) as well as a normal cell line. Furthermore, induction of apoptosis was explored through various methods, such as flow cytometry analysis, morphological changes, activation of caspase 3, ROS, and MMP.
Results: The MTT assay showed that the 5g derivative, with methoxy groups at and positions, exhibited the highest potency (IC = 40 μM) against the PC3 cell line. Our findings revealed that compound 5g induced apoptosis in the PC3 cell line, which was demonstrated by activation of caspase 3, an increase in ROS levels, and early apoptosis percentage.
Conclusion: These results suggest that compound 5g holds promise as a potential therapeutic approach to cancer treatment.
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| http://dx.doi.org/10.2174/1871520623666230504101651 | DOI Listing |
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