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Targeting the biology of aging with mTOR inhibitors. | LitMetric

Targeting the biology of aging with mTOR inhibitors.

Nat Aging

Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Published: June 2023

AI Article Synopsis

  • Rapamycin, an FDA-approved drug, inhibits the mTOR protein kinase and has been shown to enhance health and lifespan in various organisms.
  • Current research is focusing on targeting mTORC1 specifically to address aging-related diseases, with recent clinical trials examining the safety and effectiveness of mTOR inhibitors for these conditions.
  • The article also explores future developments in safer, more selective mTORC1 inhibitors and outlines the remaining challenges and questions that need to be tackled for these treatments to become mainstream for aging diseases.

Article Abstract

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model organisms. More recently, specific inhibition of mTORC1 to treat aging-related conditions has become the goal of basic and translational scientists, clinicians and biotechnology companies. Here, we review the effects of rapamycin on the longevity and survival of both wild-type mice and mouse models of human diseases. We discuss recent clinical trials that have explored whether existing mTOR inhibitors can safely prevent, delay or treat multiple diseases of aging. Finally, we discuss how new molecules may provide routes to the safer and more selective inhibition of mTOR complex 1 (mTORC1) in the decade ahead. We conclude by discussing what work remains to be done and the questions that will need to be addressed to make mTOR inhibitors part of the standard of care for diseases of aging.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330278PMC
http://dx.doi.org/10.1038/s43587-023-00416-yDOI Listing

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