AI Article Synopsis
- Researchers are exploring how blood-borne factors influence tissue interactions and the body's response to physical activity, moving beyond single molecule studies to evaluate the overall organism's response.
- A new proteomic study in mice identified over 200 protein pairs released by various cell types in response to exercise, revealing many proteins not previously associated with exercise.
- Notably, liver-secreted proteins related to carboxylesterases showed benefits in combating obesity and diabetes while enhancing exercise performance.
Article Abstract
There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk and function as molecular effectors of physical activity. Although past studies have focused on an individual molecule or cell type, the organism-wide secretome response to physical activity has not been evaluated. Here, we use a cell-type-specific proteomic approach to generate a 21-cell-type, 10-tissue map of exercise training-regulated secretomes in mice. Our dataset identifies >200 exercise training-regulated cell-type-secreted protein pairs, the majority of which have not been previously reported. Pdgfra-cre-labeled secretomes were the most responsive to exercise training. Finally, we show anti-obesity, anti-diabetic, and exercise performance-enhancing activities for proteoforms of intracellular carboxylesterases whose secretion from the liver is induced by exercise training.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524249 | PMC |
| http://dx.doi.org/10.1016/j.cmet.2023.04.011 | DOI Listing |
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