In scanning electron microscopy (SEM), a four quadrants backscattered electron detector (FQBSD) provides signals that can be combined to obtain a tridimensional reconstruction of the surface. The main challenge of the reconstruction operation consists of integrating the gradient field obtained as the normalized signal difference from each pair of opposite quadrants. Owing to the presence of electronic noise that eventually turns into image noise, a least square integration approach has been widely adopted for surface reconstruction. In the present work, we demonstrate the possibility of adopting regularization techniques (Tichonov's and Dirichlet's) to the surface reconstruction from FQBSD images to reduce the distortions due to sensitivity variations amongst the detector quadrants or an imprecise alignment of the FQBSD with the gun axis. This allows for a substantial improvement in the 3D surface reconstruction quality in terms of resolution and reduction of artifacts. These procedures have been experimentally validated on AISI 316L stainless steel polished surfaces with hardness indentation and on laser-patterned aluminum and silicon samples showing promising results.
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http://dx.doi.org/10.1016/j.ultramic.2023.113746 | DOI Listing |
Phys Med Biol
January 2025
National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, JAPAN.
PET has become an important clinical modality but is limited to imaging positron emitters. Recently, PET imaging withZr, which has a half-life of 3 days, has attracted much attention in immuno-PET to visualize immune cells and cancer cells by targeting specific antibodies on the cell surface. However,Zr emits a single gamma ray at 909 keV four times more frequently than positrons, causing image quality degradation in conventional PET.
View Article and Find Full Text PDFACS Sens
January 2025
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun 130012, China.
Superior to traditional multiplex photoelectrochemical (PEC) sensors, integrated multitarget assay on a single reconstructive electrode interface is promising in real-time detection through eliminating the need of specialized instrumentation and cumbersome interfacial modifications. Current interface reconstruction approaches including pH modulation and bioenzyme cleavage involve biohazardous and time-consuming operations, which cannot meet the demand for rapid, eco-friendly, and portable detection, which are detrimental to the development of multiplex PEC sensors toward portability. Herein, we report a pioneer work on IR-driven "four-to-one" multisignal conditioning to facile reconfigure electrode interface for multitarget detection via photoelectrochemical/photothermal dual mode.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Background: Mild Behavioral Impairment (MBI) is the onset of sustained neuropsychiatric symptoms that are considered as a possible precursor to neurodegenerative conditions, especially dementia. The concept of MBI recognizes that behavioral changes may be an early sign of brain changes due to neurodegeneration. Very recent research has shown behavioral changes in MBI might be linked to changes in brain structure, including cortical thickness.
View Article and Find Full Text PDFShock
December 2024
Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Background: Loss of muscle mass and strength in patients who have experienced severe burns is dramatic and associated with subsequent functional impairment. Past work has shown that exercise and oxandrolone, an anabolic steroid, individually improve muscle function and muscle mass in severely burned patients. This study aims to evaluate the effect of oxandrolone treatment combined with resistance exercise on muscle atrophy and investigate the protein synthesis and mitochondrial biogenesis pathways in a hindlimb suspension model.
View Article and Find Full Text PDFAesthet Surg J
January 2025
Department of Dermatology, Erasmus Universiteit Rotterdam, Rotterdam, Netherlands.
Background: Midfacial aging involves skeletal changes, muscle weakening, and fat redistribution, resulting in volume loss, skin sagging, and deepened nasolabial folds. High-Intensity Facial Electrical Stimulation (HIFES) combined with Radiofrequency (RF) is a novel non-invasive method to address these changes by enhancing muscle mass and remodeling subcutaneous tissue.
Objectives: To assess the efficacy of HIFES and Synchronized RF in improving midfacial aesthetics, specifically muscle thickness, skin displacement, and facial volume.
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