An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.

PLoS Biol

Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, United States of America.

Published: May 2023

AI Article Synopsis

  • Gasdermins are proteins that create pores in cell membranes and play roles in cell death and inflammation.
  • A recent study published in PLOS Biology examines how gasdermins have evolved across different animal species.
  • The research emphasizes the similarities and differences in the structure and function of gasdermin E among these species.

Article Abstract

The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation and divergence of gasdermin E.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159131PMC
http://dx.doi.org/10.1371/journal.pbio.3002103DOI Listing

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