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Drug Development.
Alzheimers Dement
December 2024
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Genome-wide association studies (GWAS) have identified close to one hundred loci associated with Alzheimer's disease (AD) risk. However, for most of these loci we do not understand the underlying mechanism leading to disease. Crispr genome editing in human induced pluripotent stem cells (hiPSCs) provides a model system to study the effects of these genetic variants in a disease relevant cell type.
View Article and Find Full Text PDFRenal function and risk of gestational diabetes mellitus: the potential mediating role of carnitine metabolites.
J Clin Endocrinol Metab
December 2024
Section of Epidemiology and Population Health & Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu Sichuan, 610041, China.
Context: Renal function may play a crucial role in the development of gestational diabetes mellitus (GDM). However, prospective studies on this topic are scarce and the mechanisms remain unclear.
Objective: To assess the associations of early-pregnancy renal function with GDM and the mediating role of carnitine metabolites.
Toxoplasma gondii Infection of BALB/c Mice Perturbs Host Neurochemistry.
Parasite Immunol
November 2024
Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Article Synopsis
- Toxoplasma gondii infection is linked to behavioral changes in rodents and psychoneurological diseases in humans, but the specific mechanisms are not fully understood.
- The study uses a multi-omics approach involving LCMS and RNAseq to analyze the neurochemistry and gene expression changes in BALB/c mice, which are resistant to severe infection effects.
- Results show significant alterations in specific metabolic pathways and immune-related genes during infection, highlighting the BALB/c mouse as a valuable model for understanding T. gondii's impact on the brain and identifying potential therapeutic targets.
Age-Associated Alterations in the Metabolome of Human Vitreous in Bacterial Endophthalmitis.
Invest Ophthalmol Vis Sci
November 2024
Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.
Purpose: Endophthalmitis is a severe inflammatory condition due to intraocular infections that often leads to irreversible blindness. This study aimed to understand the age-dependent metabolic alterations in the vitreous of patients with bacterial endophthalmitis.
Methods: The study included the vitreous metabolome of patients with bacterial endophthalmitis (group 1, n = 15) and uninfected controls (group 2, n = 14), which were further stratified into three groups according to their age: young (0-30 years), middle (31-60 years), and elderly (>60 years).
Causal relationship and mediation effects of immune cells and plasma metabolites in atopic dermatitis: A Mendelian randomization study.
Medicine (Baltimore)
October 2024
School of Basic Medicine, Southwest Medical University, Luzhou, Sichuan, China.
Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology involving genetic, environmental, and immunological factors. This study employs Mendelian randomization to explore the causal relationships between immune cell phenotypes and AD, and the mediating effects of plasma metabolites. Using data from European cohorts, we identified 7 immune cell phenotypes significantly associated with AD.
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