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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10336321 | PMC |
| http://dx.doi.org/10.37201/req/003.2023 | DOI Listing |
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Dual surrogate imprinting: an innovative strategy for the preparation of virus-selective particles.
Mater Horiz
January 2025
Institute of Analytical and Bioanalytical Chemistry, Ulm University, 89081, Ulm, Germany.
This work involves the preparation of dual surrogate-imprinted polymers (D-MIPs) for the capture of SARS-CoV-2. To achieve this goal, an innovative and novel dual imprinting approach using carboxylated-polystyrene (PS-COOH) nanoparticles with a diameter of 100 nm and a SARS-CoV-2 Spike-derived peptide was carried out at the surface of amine-functionalized silica (PS-NH) microspheres with a diameter of 500 nm. Firstly, PS-COOH nanoparticles with the same size and spherical shape as the SARS-CoV-2 virus were employed to form hemispherical indentations (HI) at the surface of the PS-NH microspheres (obtaining dummy particle-imprinted polymers, HI-MIPs).
View Article and Find Full Text PDFHarnessing cell aggregates for enhanced adeno-associated virus manufacturing: Cultivation strategies and scale-up considerations.
Biotechnol Prog
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AdBIOPRO, VINNOVA Competence Centre for Advanced Bioproduction by Continuous Processing, Royal Institute of Technology (KTH), Stockholm, Sweden.
The possibility to produce recombinant adeno-associated virus (rAAV) by adherent HEK293T cells was studied in a stirred tank bioreactor (STR) culture of cell aggregates. A proof-of-concept of rAAV production was successfully demonstrated in a process where single cells were first expanded, then cell aggregates were formed by dilution into a different medium 1 day before triple plasmid transfection was conducted. An alternative approach for the STR inoculation using a seed taken from a high cell density perfusion (HCDP) culture was also investigated.
View Article and Find Full Text PDFNavigating Regulatory Frameworks and Compliances for Bacteriophages as Therapeutic Agents.
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Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
The emergence of multiple antibiotic resistance in recurrent bacterial infections has led to exploring alternative therapeutic options, including using bacteria lysing viruses [bacteriophages] to control recalcitrant infections. Bacteriophages [Phage] and their end products such as enzymes, virus-like particles, and vectors are being used for varied applications such as basic and applied research for the field of phage therapeutics. Phage-based products and services such as viral vectors for gene therapy/vaccines, imaging agents, diagnostics as well as drug delivery agents form a wide range of useful innovative therapeutics that are under development.
View Article and Find Full Text PDFCharacterization and genome analysis of a novel phage BP15 infecting Vibrio parahaemolyticus.
Sci Rep
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Institute of Marine Biology, National Taiwan Ocean University, No. 2, Pei-Ning Road, Keelung, 20224, Taiwan, ROC.
Vibrio parahaemolyticus is pathogenic to both humans and marine animals. Antimicrobial-resistant (AMR) bacteria have been reported to cause mortalities in shrimp, with phage therapy presenting an alternative and eco-friendly biocontrol strategy for controlling bacterial diseases. Therefore, this study aimed to isolate and characterize phages for their applicability in lysing Vibrio parahaemolyticus.
View Article and Find Full Text PDFEnhanced antimicrobial effects of carvacrol against methicillin-resistant Staphylococcus aureus strains using niosome formulations.
Rev Argent Microbiol
January 2025
Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
Methicillin-resistant Staphylococcus aureus (MRSA) causes a wide range of infections and contributes to elevated morbidity, mortality, and healthcare costs. Herbal compounds combined with drug delivery systems could be an effective alternative option for treating resistant bacteria. This study evaluates the antimicrobial prowess of carvacrol-loaded niosomes against MRSA strains.
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