In the past decades, translocator protein (TSPO) has been considered as an biomarker to measure the presence of neuroinflammatory reactions. In this study, expression of TSPO was quantified via [F]DPA-714 positron emission tomography-magnetic resonance imaging (PET-MRI) to investigate the effects of microglial activation associated with motor behavioral impairments in the 6-hydroxydopamine (6-OHDA)-treated rodent model of Parkinson's disease (PD). [F]FDG PET-MRI (for non-specific inflammation), [F]D-FP-(+)-DTBZ PET-MRI (for damaged dopaminergic (DA) neurons), post-PET immunofluorescence, and Pearson's correlation analyses were also performed. The time course of striatal [F]DPA-714 binding ratio was elevated in 6-OHDA-treated rats during 1-3 weeks post-treatments, with peak TSPO binding in the 1st week. No difference between the bilateral striatum in [F]FDG PET imaging were found. Moreover, an obvious correlation between [F]DPA-714 SUV and rotation numbers was found ( = 0.434, * = 0.049). No correlation between [F]FDG SUV and rotation behavior was found. [F]DPA-714 appeared to be a potential PET tracer for imaging the microglia-mediated neuroinflammation in the early stage of PD.
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http://dx.doi.org/10.1021/acschemneuro.3c00202 | DOI Listing |
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