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Background: There is an urgent need for new therapeutic and diagnostic targets for Alzheimer's disease (AD). Dementia afflicts roughly 55 million individuals worldwide, and the prevalence is increasing with longer lifespans and the absence of preventive therapies. Given the demonstrated heterogeneity of Alzheimer's disease in biological and genetic components, it is critical to identify new therapeutic approaches.
View Article and Find Full Text PDFDrug Development.
Alzheimers Dement
December 2024
Yonsei University, Incheon, Incheon, Korea, Republic of (South).
Background: As amyloid-β (Aβ) aggregates are considered as the biomarkers and key factors in the pathology of Alzheimer's disease, there has been extensive investigation into Aβ-targeting compounds for the development of diagnostics and drug discovery related to the disorder. However, the polymorphic and heterogenous nature of Aβ aggregates impedes the structural understanding of their structure. Consequently it is a major challenge to develop new diagnostic and therapeutic development of AD and to study the mechanism of Aβ-targeting compounds.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
WellBe Senior Medical, Atlanta, GA, USA.
Background: Patterns of human movement evolve as an individual experiences the progression from cognitively intact (CIN) to mild cognitive impairment (MCI) and finally dementia and Alzheimer's Disease (AD). Quantification of movement with the goal of identifying MCI though step counts alone do not take into consideration the floor layout of a home. Cyclomatic complexity is an approach to normalizing differences in the individual's living space to better predict the transition from CIN to MCI.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.
Background: Promising elements of assistive technologies are available to help people with cognitive impairment in their daily lives. However, there has been limited research on how smartwatches can directly interact with persons who have cognitive impairments. We looked at the factors that affect the effectiveness of interventions provided via a smartwatch.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
Indiana University School of Medicine, Indianapolis, IN, USA.
Current joint practice guidelines (PG) on genetic counseling and testing for Alzheimer's disease (AD), published in 2011 by the National Society of Genetic Counselors (NSGC) and American College of Medical Genetics), recommend against clinical APOE genetic testing. These recommendations were largely followed, as seen in a survey of AD Research Centers in 2019 where only 7% of centers reported disclosure of APOE to research participants. However, because the risk of amyloid related imaging abnormalities (ARIA) associated with anti-amyloid therapy is increased for those with one or two copies of APOE e4, the FDA now endorses APOE testing for those considering this treatment.
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