Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jtm/taad064 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transcriptomic and Proteomic Analysis of Monkeypox Virus A5L-Expressing HEK293T Cells.
Int J Mol Sci
January 2025
Institute of Pathogenic Microorganism, Jiangxi Agricultural University, Nanchang 330000, China.
Monkeypox (MPOX) is a zoonotic viral disease caused by the Monkeypox virus (MPXV), which has become the most significant public health threat within the genus since the eradication of the Variola virus (VARV). Despite the extensive attention MPXV has garnered, little is known about its clinical manifestations in humans. In this study, a high-throughput RNA sequencing (RNA-seq) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach was employed to investigate the transcriptional and metabolic responses of HEK293T cells to the MPXV A5L protein.
View Article and Find Full Text PDFArticle Synopsis
- The monkeypox outbreak declared a public health emergency in 2022 escalated in 2024 due to a new strain identified in the Democratic Republic of the Congo and surrounding countries.
- The review utilized databases like PubMed and WHO to analyze the prevalence, treatment, and prevention strategies related to mpox, highlighting its rising cases and fatalities in African nations.
- The new mpox strain, primarily spreading through sexual networks, poses a significant global health threat, emphasizing the need for a coordinated international response to control the outbreak effectively.
Development of a luminex-based assay for the detection of anti-capripoxvirus and rift valley fever virus antibodies in domestic ruminants.
Virol J
December 2024
Animal Production and Health Laboratory, Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
The three members of the genus capripoxvirus (CaPV), lumpy skin disease virus (LSDV), sheeppox virus (SPPV), and goatpox virus (GTPV) have common hosts and areas of overlapping geographical distribution with Rift Valley fever virus (RVFV). Hence, to ensure more cost-effective disease surveillance we developed and evaluated a Luminex assay for the simultaneous detection of antibodies against CaPV and RVFV in domestic ruminants. In cattle, the assay had a sensitivity (Se) of 98.
View Article and Find Full Text PDFEvolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu.
Virol J
December 2024
Key Laboratory of Medicine, Nantong Center for Disease Control and Prevention, 189 GongnongnanRoad, Chongchuan District, Nantong, 226007, China.
Article Synopsis
- Monkeypox (MPOX) is caused by the Orthopoxvirus monkeypox (MPXV) and presents symptoms akin to smallpox, with ongoing outbreaks raising global public health concerns, especially in the Democratic Republic of the Congo and recently in China.
- A new lineage of MPXV (C.1.1) was identified from samples in a Nantong outbreak, possibly linked to cases imported from Japan.
- Genomic analysis revealed reduced mutations in MPXV and specific mutations in proteins that could affect its evolution and vaccine development, indicating potential research directions for understanding the virus.
Detecting Monkeypox Virus by Immunohistochemistry.
J Cutan Pathol
December 2024
Department of Dermatology, University of Virginia, Charlottesville, Virginia, USA.
Background: Mpox (formerly known as monkeypox), a zoonotic disease caused by Monkeypox virus (MPXV), has become an international outbreak since May 2022. Mpox often presents with a mild systemic illness and a characteristic vesiculopustular skin eruption. In addition to molecular testing, histopathology of cutaneous lesions usually shows distinctive findings, such as epidermal necrosis, balloon degeneration, papillary dermal edema, and focal dermal necrosis, which have proven helpful in the diagnosis of mpox.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!