AI Article Synopsis

  • * 32 patients were treated with a combination of Rituximab and Lenalidomide (R2) over a median follow-up of 22.6 months, but the treatment only achieved a 12.5% response rate.
  • * The results showed a median progression-free survival of 2.6 months and a median overall survival of 9.3 months, leading researchers to conclude that the R2 regimen is not advisable for high-risk patients in this group.

Article Abstract

Relapsed/Refractory Diffuse Large B Cell Lymphoma have a dismal prognosis in need of innovative treatments. This prospective phase 2 study enrolled 32 patients between 2013 and 2017 with Relapsed/Refractory Diffuse Large B Cell Lymphoma treated with Rituximab and Lenalidomide (R2). Median age was 69 years (40-86), 90.1% had received at least 2 prior lines of treatment, 81% were defined as having High Risk disease according to our criteria and ECOG performance status was > 2 in 51.6%. Patients received a median number of 2 cycles of R2 (1-12). With a median follow up of 22.6 months, the objective response rate was 12.5%. Median progression free survival was 2.6 months (95% CI, [1.7-2.9]) and median overall survival was 9.3 months (95% CI, [5.1-Not estimable]). This study therefore did not achieve its primary endpoint and the R2 regimen cannot be recommended in Relapsed/Refractory Diffuse Large B Cell Lymphoma patients with High Risk features.

Download full-text PDF

Source
http://dx.doi.org/10.1080/16078454.2023.2207948DOI Listing

Publication Analysis

Top Keywords

diffuse large
16
relapsed/refractory diffuse
12
large cell
12
cell lymphoma
12
phase study
8
high risk
8
survival months
8
months 95%
8
median
5
study lenalidomide
4

Similar Publications

In this comprehensive review, we delve into the transformative role of artificial intelligence (AI) in refining the application of multi-omics and spatial multi-omics within the realm of diffuse large B-cell lymphoma (DLBCL) research. We scrutinized the current landscape of multi-omics and spatial multi-omics technologies, accentuating their combined potential with AI to provide unparalleled insights into the molecular intricacies and spatial heterogeneity inherent to DLBCL. Despite current progress, we acknowledge the hurdles that impede the full utilization of these technologies, such as the integration and sophisticated analysis of complex datasets, the necessity for standardized protocols, the reproducibility of findings, and the interpretation of their biological significance.

View Article and Find Full Text PDF

Background: The prognostic significance of the chemokine receptor CCR7 in diffuse large B-cell lymphoma (DLBCL) has been reported previously. However, the detailed mechanisms of CCR7 in DLBCL, particularly regarding its interaction with lenalidomide treatment, are not fully understood.

Methods: Our study utilized bioinformatics approaches to identify hub genes in SU-DHL-2 cell lines treated with lenalidomide compared to control groups.

View Article and Find Full Text PDF

Single-Step Sampling Approach for Unsupervised Anomaly Detection of Brain MRI Using Denoising Diffusion Models.

Int J Biomed Imaging

December 2024

Department of Computer Science & Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education (MAHE) 576104, Manipal, Karnataka, India.

Generative models, especially diffusion models, have gained traction in image generation for their high-quality image synthesis, surpassing generative adversarial networks (GANs). They have shown to excel in anomaly detection by modeling healthy reference data for scoring anomalies. However, one major disadvantage of these models is its sampling speed, which so far has made it unsuitable for use in time-sensitive scenarios.

View Article and Find Full Text PDF

Fluid flow and amyloid transport and aggregation in the brain interstitial space.

PNAS Nexus

January 2025

Université Paris Cité, CNRS, Laboratoire de Biochimie  Théorique, 13 rue Pierre et Marie Curie, Paris 75005, France.

The driving mechanisms at the base of the clearance of biological wastes in the brain interstitial space (ISS) are still poorly understood and an actively debated subject. A complete comprehension of the processes that lead to the aggregation of amyloid proteins in such environment, hallmark of the onset and progression of Alzheimer's disease, is of crucial relevance. Here we employ combined computational fluid dynamics and molecular dynamics techniques to uncover the role of fluid flow and proteins transport in the brain ISS.

View Article and Find Full Text PDF

Primary central nervous system diffused large B-cell lymphoma (PCNS-DLBCL) is a rare type of non-Hodgkin lymphoma restricted to the central nervous system (CNS). To explore its specific pathogenesis and therapeutic targets, we performed multi-omics sequencing on tumor samples from patients diagnosed with PCNS-DLBCL, secondary CNS-DLBCL or extracranial (ec) DLBCL.By single-cell RNA sequencing, highly proliferated and dark zone (DZ)-related B cell subclusters, MKI67_B1, PTTG1_B2 and BTG1_B3, were predominant significantly in PCNS-DLBCL.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!