AI Article Synopsis
- Early-life immune development is essential for long-term health, but the factors influencing postnatal immune maturation are not well understood.
- The study focused on mononuclear phagocytes in Peyer's patches, showing significant age-related changes that led to reduced T cell priming in young organisms.
- The research identified that the differentiation of follicle-associated epithelium M cells is crucial for driving the maturation of these immune cells after weaning.
Article Abstract
Early-life immune development is critical to long-term host health. However, the mechanisms that determine the pace of postnatal immune maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches (PPs), the primary inductive site of intestinal immunity. Conventional type 1 and 2 dendritic cells (cDC1 and cDC2) and RORgt+ antigen-presenting cells (RORgt+ APC) exhibited significant age-dependent changes in subset composition, tissue distribution, and reduced cell maturation, subsequently resulting in a lack in CD4+ T cell priming during the postnatal period. Microbial cues contributed but could not fully explain the discrepancies in MNP maturation. Type I interferon (IFN) accelerated MNP maturation but IFN signaling did not represent the physiological stimulus. Instead, follicle-associated epithelium (FAE) M cell differentiation was required and sufficient to drive postweaning PP MNP maturation. Together, our results highlight the role of FAE M cell differentiation and MNP maturation in postnatal immune development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262694 | PMC |
| http://dx.doi.org/10.1016/j.immuni.2023.04.002 | DOI Listing |
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