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Dual ligand functionalized pH-sensitive liposomes for metastatic breast cancer treatment: and assessment.
J Mater Chem B
January 2025
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, 226025, India.
This research demonstrates the design and development of a novel dual-targeting, pH-sensitive liposomal (pSL) formulation of 5-Fluorouracil (5-FU), , (5-FU-iRGD-FA-pSL) to manage breast cancer (BC). The motivation to explore this formulation is to overcome the challenges of systemic toxicity and non-specific targeting of 5-FU, a conventional chemotherapeutic agent. The proposed formulation also combines folic acid (FA) and iRGD peptides as targeting ligands to enhance tumor cell specificity and penetration, while the pH-sensitive liposomes ensure the controlled drug release in the acidic tumor microenvironment.
View Article and Find Full Text PDFOptimizing oil-water separation using fractal surfaces.
J Chem Phys
January 2025
Instituto de Física, Universidade Federal do Rio Grande do Sul, Caixa Postal 15051, CEP 91501-970 Porto Alegre, Rio Grande do Sul, Brazil.
Oil has become a prevalent global pollutant, stimulating the research to improve the techniques to separate oil from water. Materials with special wetting properties-primarily those that repel water while attracting oil-have been proposed as suitable candidates for this task. However, one limitation in developing efficient substrates is the limited available volume for oil absorption.
View Article and Find Full Text PDFDiagnostic value of greyscale ultrasound combined with superb microvascular imaging in thyroid nodules: a systematic review and meta-analysis.
Quant Imaging Med Surg
January 2025
Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Superb microvascular imaging (SMI) is an advanced form of Doppler flow imaging which has advantages in tiny vessels and low-speed flow. This study aimed to evaluate the diagnostic performance of combining greyscale ultrasound (US) with SMI in differentiating between benign and malignant thyroid nodules.
Methods: A search was conducted in PubMed, Embase, Cochrane Library, Scopus, and Web of Science for relevant studies published till 25 October 2023 that investigated the combined use of greyscale US and SMI to differentiate between benign and malignant thyroid nodules.
Study of High Performance Nanoscale Channel Length Vertical Transistors with a Self-Aligned Blocking Layer.
ACS Appl Mater Interfaces
January 2025
Department of Electrical Engineering and Computer Science (EECS), Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea.
A transistor design employing all vertically stacked components has attracted considerable attention due to the simplicity of the fabrication process and the high conductivity easily realized by achieving nanolevel short channel lengths with two-dimensional current paths. However, fundamental issues, specifically the blocking of the gate electrical field to the semiconductive channel layer and high leakage current at the "off" state, have impeded this configuration in becoming a major transistor design. To address these issues, it has been proposed to introduce a blocking layer (BL) with embedded hole structures and source electrode with embedded hole structures, enhancing gate field penetration and carrier modulation.
View Article and Find Full Text PDFCombined Nanodrops Imaging and Ultrasound Localization Microscopy for Detecting Intracerebral Hemorrhage.
Ultrasound Med Biol
January 2025
Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL, USA; Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA; Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, USA. Electronic address:
Objective: Advanced imaging methods are crucial for understanding stroke mechanisms and discovering effective treatments to reduce bleeding and enhance recovery. In pre-clinical in vivo stroke imaging, MRI, CT and optical imaging are commonly used to evaluate stroke outcomes in rodent models. However, MRI and CT have limited spatial resolution for rodent brains, and optical imaging is hindered by limited imaging depth of penetration.
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