It was to explore the application effect of cone beam computed tomography (CBCT) guided bone regeneration (GBR) combined with concentrated growth factor (CGF) in the implantation of maxillary teeth with insufficient bone mass. 78 patients with single maxillary anterior tooth loss and labial alveolar defects in Dazhong Stomatological Hospital were retrospectively analyzed and randomly divided into groups A and B. Both groups were treated with surgical methods of GBR at the same time of implantation. Group A: CGF fibrin fluid and Bio-Oss bone powder, covered with CGF membrane on the surface to guide bone regeneration. Group B: Bio-Oss bone powder was implanted and covered with Heal All collagen biofilm. The horizontal bone width, keratinized gingival width, bone plate thickness, implant margin results, and alveolar ridge width were analyzed at 3 and 6 months before and after the operation in both groups. 6 months after the operation, the difference in the indexes between the two groups was evident; and in group A, the indexes had an obvious difference in contrast with those before operation; the healing rate of soft tissue was 100% in group A and 80% in group B, which was significantly different (P < 0.05). Preoperative CBCT GBR combined with CGF can promote the bone formation content of guided regeneration of bone defects in the maxillary teeth region.
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http://dx.doi.org/10.14715/cmb/2022.68.12.13 | DOI Listing |
Fracture-related infection (FRI) is a serious complication that occurs primarily in surgically treated fractures. FRIs occur when bacteria enter the site of bony injury and alter the healing inflammatory response within the bone. This can prevent bone regeneration and can lead to long-lasting complications such as chronic infection, pain, nonunion, and amputation.
View Article and Find Full Text PDFJ Biomed Mater Res B Appl Biomater
January 2025
Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Addressing the high cost and long cycle associated with the multistep digital restoration process involving 3D printing technology, we proposed the 3D pen as an innovative strategy for rapid bone repair. Capitalizing on the low melting point characteristic of polycaprolactone (PCL), we introduced, for the first time, the novel concept of directly constructing scaffolds at bone defect sites using 3D pens. In this in vitro study, we meticulously evaluated both the mechanical and biological properties of 3D pen-printed PCL scaffolds with six distinct textures: unidirectional (UNI) (0°, 45°, 90°), bidirectional (BID) (-45°/45°, 0°/90°), and concentric (CON).
View Article and Find Full Text PDFTheranostics
January 2025
Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Infectious bone defects present a significant clinical challenge, characterized by infection, inflammation, and subsequent bone tissue destruction. Traditional treatments, including antibiotic therapy, surgical debridement, and bone grafting, often fail to address these defects effectively. However, recent advancements in biomaterials research have introduced innovative solutions for managing infectious bone defects.
View Article and Find Full Text PDFAcc Mater Res
December 2024
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, United States.
As a ubiquitous feature of the biological world, gradation, in either composition or structure, is essential to many functions and processes. Taking protein gradation as an example, it plays a pivotal role in the development and evolution of human bodies, including stimulation and direction of the outgrowth of peripheral nerves in a developing fetus. It is also critically involved in wound healing by attracting and guiding immune cells to the site of injury or infection.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
Department of Biology, University of Padova, Padua, Italy.
Stat3 is a transcription factor with a key role in cell proliferation and migration. Using the zebrafish line we showed that the genetic ablation results in a marked decrease of tail fin regrowth, demonstrating that this transcription factor is fundamental in the regeneration process. Stat3 activity is finely modulated by post-translational modifications that occur in several residues of the protein (i.
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