This study aimed to investigate the role of AmpC enzymes in carbapenem resistance among AmpC/extended-spectrum β-lactamase (ESBL)-producing clinical isolates of and spp. Fifty-six bacterial strains that were AmpC producers were examined. The antibiotic susceptibility test was performed by the disk diffusion and E-test. The prevalence of the plasmid carbapenemase was determined using PCR. The resistance to meropenem in the AmpC/ESBL group was 64%, higher than that reported for the AmpC/ESBL group. Ten isolates of the carbapenem-resistant AmpC producers were negative for carbapenemase-encoding genes. Carbapenem resistance among AmpC-producing isolates with negative results for carbapenemase-encoding genes potentially demonstrates the role of AmpC enzymes among these isolates.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/fmb-2021-0211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug-Resistant Bacteria in Ugandan Communities: A Retrospective Analysis.
Glob Health Epidemiol Genom
January 2025
Center for Comparative Epidemiology, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, Room A109, East Lansing, Michigan 48824, USA.
Cockroaches could play a role in the transmission dynamics of antimicrobial-resistant bacteria (ARB) at variable interfaces in Ugandan communities, acting as both reservoirs and vectors. This study investigated the burden and diversity of ARB carried by cockroaches in human settlements in Uganda, so as to understand their role in the spread of these pathogens and their potential as sentinels in antimicrobial resistance (AMR) surveillance programs. A retrospective analysis was conducted on two unpublished studies by Makerere University students.
View Article and Find Full Text PDFFecal Carriage and Risk Factors Associated with Extended-Spectrum β-Lactamase-/AmpC-/Carbapenemase-Producing in Dogs from Italy.
Animals (Basel)
November 2024
Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.
MDR bacteria are an emerging global threat to public health, and the role of dogs in the rise of antimicrobial resistance is under investigation. This study investigated the fecal shedding of extended-spectrum β-lactamase (ESBL)-, AmpC- and carbapenemase (CP)-producing and associated risk factors in dogs admitted to the Veterinary Teaching Hospital of Lodi, University of Milan, or other veterinary clinics and kennels in Northen Italy. Feces collected in 2020-2022 were microbiologically and molecularly analyzed.
View Article and Find Full Text PDFOccurrence, Multidrug Resistance, and Multilocus Sequence Typing of Extended-Spectrum Beta-Lactamase/AmpC-Producing from Farmed Eggs.
Foodborne Pathog Dis
October 2024
Department of Veterinary and Animal Husbandry Extension Education, Guru Angad Dev Veterinary and Animal Sciences University (GADVASU), Punjab, India.
The present study evaluated the occurrence, antibiogram profile, and sequence types (STs) of multidrug resistant (MDR) from freshly laid eggs ( = 480), feed ( = 24), water ( = 24), poultry droppings ( = 24), and hand swab samples ( = 10) collected from 24 deep litter (DL) and caged poultry layer farms (12 per category) across Punjab, India. The overall contamination rate in DL and cage farms was 32% (95% confidence intervals [CI], 26.6-37.
View Article and Find Full Text PDFTemporal dynamics of extended-spectrum β-lactamase-producing Escherichia coli and carbapenemase-producing Gram-negative bacteria in hospital wastewater.
Sci Total Environ
December 2024
Department of Health and Medical Sciences, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan; Department of Medical Sciences, Shinshu University Graduate School of Medicine, Science and Technology, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan. Electronic address:
Hospital wastewater is a reservoir for the environmental spread of clinically relevant antimicrobial-resistant bacteria and resistance genes. The aim of this study was to quantify total Escherichia coli, extended-spectrum β-lactamase (ESBL)-producing E. coli, and carbapenemase-producing organisms (CPOs) and perform whole-genome sequencing-based characterization of these bacterial isolates in hospital wastewater samples collected bimonthly in Japan from January to November 2021.
View Article and Find Full Text PDFEnterobacterales Producing ESBLs and AmpC in Fresh Vegetables from Tebessa City, Algeria.
Microb Drug Resist
November 2024
Laboratory of Microorganisms and Active Biomolecules, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Article Synopsis
- - The study assessed contamination levels of fresh produce by ESBLs-producing Enterobacterales and AmpC-producing Enterobacterales in Tebessa, Algeria, analyzing 132 samples (67 vegetables and 65 fruits).
- - Results showed a 19.40% prevalence of resistant Enterobacterales in vegetables, while fruits tested negative; all isolates exhibited multidrug resistance with notable resistance to most β-lactams.
- - Genetic analysis identified several uncommon ESBL gene variants in seven strains, with a specific gene showing dominance, highlighting significant contamination in vegetables and the emergence of new resistance genes in Algeria.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!