The hypotensive effect and interrelations of some hemodynamic parameters in the course of intravenous administration of sodium nitroprusside (SNP) were examined in an experimental study in cats with induced hypertension. Both in normotensive and hypertensive conditions, the SNP injection produced an almost instantaneous drop in systolic and diastolic ABP, its principal mechanisms being the depression of total peripheral resistance (TPR). The magnitude of decrease in stroke and minute volumes was dependent on the extent of ABP fall that was in turn related to the dose of the drug and the baseline TPR values.
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