The League of European Accelerator-based Photon Sources (LEAPS), comprising 19 large-scale user facilities in 10 member and associated states, has put forward for the first time a European strategy for a transformative way of cooperation, thereby mobilizing the members' substantial expertise in photon science and technology, in infrastructure management and service to users and stakeholders. This European Strategy for Accelerator-based Photon Sources-ESAPS 2022-is a coherent pan-European plan addressing the future challenges and needs of the new era in research and innovation, designed to put Europe in a global leadership position in important future key technologies. In ESAPS2022, ambitious facility upgrades and technology development plans as well as a new strategic challenge-driven use of these facilities are discussed.
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http://dx.doi.org/10.1140/epjp/s13360-023-03947-w | DOI Listing |
Expert Rev Med Devices
January 2025
Italian Society of Hospital Pharmacy (SIFO), SIFO Secretariat of the Lombardy Region, Milan, Italy.
Introduction: Digital therapeutics (DTx) are an emerging phenomenon within the scientific landscape which is attracting considerable international interest. This review aimed to provide an overview of the definition and classification of DTx, focusing on the contribution that DTx may provide in the treatment of a lot of diseases, compared with pharmacological treatments and highlighting it strengthens and weaknesses into the European regulatory landscape.
Areas Covered: They are software-generated therapeutic interventions directly to patients useful to prevent, manage or treat diseases.
Nucleic Acid Ther
January 2025
Global Preclinical Safety, AbbVie Inc., North Chicago, Illinois, USA.
The Oligonucleotide Nonclinical Working Group (WG) of the European Federation of Pharmaceutical Industries and Associations conducted an industry survey to understand current practices and regulatory expectations for genotoxicity and carcinogenicity assessment of oligonucleotide therapeutics (ONTs), along with historical genotoxicity testing results. The survey, involving 29 pharmaceutical and biotechnology companies, revealed a consistent absence of genotoxicity across a diverse range of oligonucleotide classes and chemistries, consistent with previous observations. Despite the lack of genotoxicity, companies continue to follow standard testing guidelines, with only limited divergence.
View Article and Find Full Text PDFDemography
January 2025
Department of Political and Social Sciences, European University Institute, Florence, Italy.
Educational disparities in mothers' parenting time have implications for socioeconomic inequality in children's resources and later life attainment. The reproduction of inequality could be more consequential if educational disparities are most pronounced at child ages when a specific parenting need is more developmentally important. Following recent findings suggesting a general reduction in the educational gradient in mothers' overall parenting time, this study aims to determine if this convergence extends to the developmental gradient in parenting.
View Article and Find Full Text PDFJ Funct Morphol Kinesiol
January 2025
Observational Research Group, Faculty of Education and Sport, University of Vigo, 36005 Pontevedra, Spain.
Pickleball has experienced remarkable growth in recent years, yet studies exploring its specific characteristics are scarce. This investigation provides a detailed notational analysis of women's singles pickleball, evaluating the technical and tactical performance indicators in the game. An observational methodology was used to analyze all points from five PPA Tour tournaments.
View Article and Find Full Text PDFExpert Opin Pharmacother
January 2025
Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Milan, Italy.
Introduction: . The PI3K pathway is crucial in breast cancer (BC), influencing cell survival, growth, and metabolism, with AKT playing a central role in treatment resistance. This pathway's involvement in breast carcinogenesis and its link to treatment resistance underscores the significance of targeting it in BC therapy.
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