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Urinary oxidative stress biomarkers in nephrotoxicity induced by PM in a rat model.
Inhal Toxicol
January 2025
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.
Objective: The present study evaluated urinary oxidative stress (OxS) biomarkers to explain the extrapulmonary effect of renal function decline due to subchronic inhalation exposure to particles smaller than 2.5 μm, as well as the correlation of the biomarkers with the particles' endotoxin content.
Materials And Methods: Adult male Sprague-Dawley rats were exposed to subchronic inhalation of particles smaller than 2.
Recombinant Factor C as an In Vitro Assay for the Residual Pathogenicity Evaluation of Veterinary Autogenous Vaccines.
Vet Sci
December 2024
Istituto Zooprofilattico Sperimentale Dell'Umbria e Delle Marche "Togo Rosati", via G. Salvemini 1, 06126 Perugia, Italy.
Background: Veterinary autogenous vaccines, similar to all injectable pharmaceutical products, must be tested to assess endotoxin concentrations. The Limulus Amebocyte Lysate Test (LAL test) is widely used in in vitro quality control assays for endotoxin detection, although it presents some ethical issues related to the production of reagents and is also characterized by a low specificity due to other contaminants that can activate the reaction. For all these reasons, a new recombinant factor C LAL test was developed.
View Article and Find Full Text PDFSERIAL HEALTH ASSESSMENT WITH STANDARDIZED EXTERNAL SCORING AND HEMOLYMPH EVALUATION IN THE AMERICAN HORSESHOE CRAB ().
J Zoo Wildl Med
December 2024
National Aquarium, Baltimore, MD 21202, USA.
Serial health assessment of a managed population of American horseshoe crabs (HSC; ) was performed. Twenty HSC were examined once a month for 7 mon; this included a physical exam with a standardized scoring sheet, HR, morphometrics, and hemolymph evaluation with hemocyte count, copper concentration, and biochemistry panel. The HSC in this population had varying levels of external lesions at enrollment.
View Article and Find Full Text PDFHistopathological and histochemical analysis of the digestive tract of adult horseshoe crabs under mercury stress.
Aquat Toxicol
December 2024
South China Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Guangzhou 510300, China; Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs of China, Guangzhou 510300, China; Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, Guangzhou 510300, China; Sanya Tropical Fisheries Research Institute, Sanya, Hainan 572019, China. Electronic address:
Mercury (Hg) contamination is a major environmental concern that continuously impacts marine organisms, including the mangrove horseshoe crab (Carcinoscorpius rotundicauda). As a vulnerable species, C. rotundicauda holds significant ecological and evolutionary value, making it particularly susceptible to Hg pollution and deserving of focused conservation efforts.
View Article and Find Full Text PDFThe impact of LPS mutants on endotoxin masking in different detection systems.
Biologicals
February 2025
Microcoat Biotechnologie GmbH, Am Neuland 3, 82347, Bernried Am Starnberger See, Germany. Electronic address:
Endotoxin masking poses a potential risk to patient safety by rendering endotoxin undetectable. While research often focuses on international endotoxin standards (RSE), the effects of LPS mutants on Low Endotoxin Recovery (LER) are poorly understood. Our study investigated S.
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