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http://dx.doi.org/10.1186/s13098-023-01066-1 | DOI Listing |
Pharmaceutics
January 2025
Department of Nanomedicine and Advanced Technologies, California Innovations Corporation, San Diego, CA 92037, USA.
In the original publication [...
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
In the original publication [...
View Article and Find Full Text PDFPharmaceutics
December 2024
Pharmathen SA, 31 Spartis Str., 14452 Metamorfosi Attica, Greece.
Regulatory authorities typically require bioequivalence to be demonstrated by comparing pharmacokinetic parameters like area under the plasma concentration-time curve (AUC) and maximum plasma concentration (C). Because in certain cases, AUC and C alone may not be adequate to identify formulation differences in early and/or late segments of the dosing interval, partial AUCs (pAUCs) have been proposed as additional metrics to evaluate bioequivalence. Even though cut-off points for pAUCs are usually decided based on clinical relevance, the identification of the correct cut-off range remains elusive in many other cases and tends to contribute to increased pAUC estimate variabilities.
View Article and Find Full Text PDFNutrients
January 2025
Pediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Liebigstr 20a, Haus 6, 04103 Leipzig, Germany.
Background/objectives: Although approximately 160 human milk oligosaccharides (HMOs) have been identified, current studies on HMO quantitation are limited to the 10-19 most abundant HMOs. We assessed the variations in the relative concentrations of 71 HMO structures over lactation in human milk samples by an advanced liquid chromatography-mass spectrometry approach.
Methods: Samples were collected from 64 mothers at 6 weeks, 6 months, and 12 months of lactation in the Ulm SPATZ Health Study, a German birth cohort.
Nutrients
January 2025
Department of Nursing and Physiotherapy, University of Lleida, Montserrat Roig St, 2, 25198 Lleida, Spain.
Background: Dehydration and low fluid intake cause the most prevalent electrolyte imbalance in older adults and increase their morbi-mortality.
Objective: To analyse the scientific production on dehydration in older adults.
Methods: A bibliometric analysis was performed using the Web of Science Core Collection database.
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