AI Article Synopsis
- * Nrf2 inhibitors are emerging as important targets for cancer research, and natural plant-based remedies containing phytochemicals, especially phenolic compounds, show promise in cancer prevention.
- * The review highlights the potential of phenolic compounds and other bioactive agents as anticancer therapies through their ability to inhibit Nrf2, with a focus on their clinical applications.
Article Abstract
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. Video Abstract.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152593 | PMC |
| http://dx.doi.org/10.1186/s12964-023-01109-0 | DOI Listing |
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