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Ethanol Chemical Gallbladder Ablation for Cholecystitis in Inoperable Elderly Patients.

Cardiovasc Intervent Radiol

November 2024

Service de Radiologie Interventionnelle, Centre Hospitalier Sud Francilien, 40 Avenue Serge Dassault, 91100, Corbeil-Essonnes, France.

Purpose: Cholecystitis presents significant treatment challenges, especially in elderly patients with high surgical or anesthetic risks. While cholecystectomy remains the standard intervention, its feasibility is sometimes limited, leading to reliance on cholecystostomy, which has a high recurrence rate and does not address the underlying cause. The aim was to evaluate the efficacy and safety of chemical gallbladder ablation as a minimally invasive treatment option for acute cholecystitis in elderly and comorbid patients.

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Article Synopsis
  • Severe acute cholecystitis (AC) is a serious condition that can cause systemic infections and organ dysfunction, prompting a study on the best timing and effectiveness of surgery and pre-operative drainage methods.
  • The research involved 142 patients who were divided into early cholecystectomy (EC) within 72 hours of symptoms and delayed cholecystectomy (DC), along with their surgical outcomes compared.
  • Findings showed that patients eligible for EC had better surgical results, while preoperative percutaneous cholecystostomy (PC) reduced intraoperative bleeding and hospital stays but was linked to higher rates of complications in those with cardiovascular issues or taking warfarin.
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Expanded analysis for patients with acute cholecystitis indicates outcomes vary based on COVID-19 status and treatment modality.

J Gastrointest Surg

July 2024

Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida, United States; Department of Surgical Oncology, Moffitt Cancer Center, Tampa, Florida, United States.

Background: The impact of different phases of COVID-19 infection on outcomes from acute calculous cholecystitis (ACC) is not well understood. Therefore, we examined outcomes of acute cholecystitis during the COVID-19 pandemic, comparing the effect of different treatment modalities and COVID-19 infection status. We hypothesized that patients with acute COVID-19 would have worse outcomes than COVID-negative patients, but there would be no difference between COVID-negative and COVID-recovered patients.

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 The aim of this study was to report technical and clinical success of bedside ultrasound-guided percutaneous cholecystostomy (PC) tube placement in intensive care unit (ICU).  This is a retrospective study of 51 patients (36 males:15 females, mean age: 67 years) who underwent ultrasound-guided PC from May 2015 to January 2020. The indication for cholecystostomy tube placement, comorbidities, imaging finding, technical success, clinical success, timing of surgery post-cholecystostomy tube placement, indwelling catheter time, complications, and follow-up were recorded.

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Introduction: Percutaneous cholecystostomy (PCT) is an alternative to cholecystectomy (CCY) in high-risk surgical candidates with severe acute cholecystitis. A subset of these patients ultimately undergo delayed CCY. We therefore compared outcomes of delayed CCY in patients with grade III acute cholecystitis who received a PCT on index admission, to those who did not.

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