AI Article Synopsis
- The study aimed to compare the changes over time in specific measurements of retinal structures (ellipsoid zone and retinal pigment epithelium) with areas of abnormal autofluorescence in patients with ABCA4-associated retinopathy.
- Researchers analyzed SD-OCT scans from 20 patients over an average of 2.6 years, measuring the extent of retinal damage and changes in autofluorescence areas.
- Results indicated that the rate of ellipsoid zone loss was higher than that of retinal pigment epithelium loss, suggesting that SD-OCT could effectively monitor retinal health and could serve as an alternative to traditional autofluorescence methods.
Article Abstract
Purpose: To compare longitudinal changes in en face spectral domain-optical coherence tomography (SD-OCT) measurements of ellipsoid zone (EZ) and retinal pigment epithelium (RPE) loss to changes in the hypoautofluorescent and hyperautofluorescent (AF) areas detected with short-wavelength (SW)-AF in ABCA4-associated retinopathy.
Methods: SD-OCT volume scans were obtained from 20 patients (20 eyes) over 2.6 ± 1.2 years (range 1-5 years). The EZ, and RPE/Bruch's membrane boundaries were segmented, and en face slab images generated. SubRPE and EZ slab images were used to measure areas of atrophic RPE and EZ loss. These were compared to longitudinal measurements of the hypo- and abnormal AF (hypoAF and surrounding hyperAF) areas.
Results: At baseline, the en face area of EZ loss was significantly larger than the subRPE atrophic area, and the abnormal AF area was significantly larger than the hypoAF area. The median rate of EZ loss was significantly greater than the rate of increase in the subRPE atrophic area (1.2 mm2/yr compared to 0.5 mm2/yr). The median rate of increase in the abnormal AF area was significantly greater than the increase in the hypoAF area (1.6 mm2/yr compared to 0.6 mm2/yr).
Conclusions: En face SD-OCT can be used to quantify changes in RPE atrophy and photoreceptor integrity. It can be a complementary or alternative technique to SW-AF with the advantage of monitoring EZ loss. The SW-AF results emphasize the importance of measuring changes in the hypo- and abnormal AF areas.
Translational Relevance: The findings are relevant to the selection of outcome measures for monitoring ABCA4-associated retinopathy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153573 | PMC |
| http://dx.doi.org/10.1167/tvst.12.5.2 | DOI Listing |
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