AI Article Synopsis
- Idiopathic inflammatory myopathies (IIM) are uncommon diseases marked by inflammation in skeletal muscles and frequent pulmonary issues like interstitial lung disease (ILD), often leading to varying severity from chronic to rapidly progressive forms.* -
- Managing myositis-related ILD (M-ILD) is challenging for healthcare professionals due to the lack of clear treatment guidelines, resulting in a reliance on immunosuppressive and non-drug therapies.* -
- The review outlines current pharmacological options, their dosages, side effects, and presents a treatment framework for addressing both chronic and rapidly progressive ILD cases associated with M-ILD.*
Article Abstract
Idiopathic inflammatory myopathies (IIM) are rare disorders characterised by the presence of skeletal muscle inflammation, with interstitial lung disease (ILD) being the most frequent pulmonary manifestation. The spectrum of clinical presentations of myositis related ILD (M-ILD) encompasses a chronic process to a rapidly progressive ILD (RP-ILD); which is associated with a high mortality rate. The most effective treatments remain controversial and poses a unique challenge to both rheumatologists and respiratory physicians to manage. Given the rare heterogenous nature of M-ILD, there is a paucity of data to guide treatment. The cornerstone of existing treatments encompasses combinations of immunosuppressive therapies, as well as non-pharmacological therapies. In this review, we aim to summarize the current pharmacological therapies (including its dosing regimens and side effects profiles) and non-pharmacological therapies. Based on the existing literature to date, we propose a treatment algorithm for both chronic M-ILD and RP-ILD.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185598 | PMC |
| http://dx.doi.org/10.1007/s00296-023-05336-z | DOI Listing |
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