We have developed a new three-component catalytic coupling reaction of alkynyl boronates, diazomethanes, and aliphatic/aromatic ketones in the presence of BINOL derivatives. The reaction proceeds with a remarkably high enantio- and diastereoselectivity (up to three contiguous stereocenters) affording tertiary CF-allenols in a single operational step. The reaction proceeds under mild, neutral, metal-free conditions, which leads to a high level of functional group tolerance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176480 | PMC |
| http://dx.doi.org/10.1021/jacs.3c02852 | DOI Listing |
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