Background: is a multidrug-resistant organism with limited antibiotic treatment options. Minocycline and doxycycline may be appropriate, but clinical data are limited.
Objective: To compare tetracyclines (minocycline and doxycycline [TCN]) with standard of care, sulfamethoxazole-trimethoprim (TMP-SMZ), in pneumonia treatment.
Methods: This retrospective, 2-center study evaluated patients treated for pneumonia with TCN or TMP-SMZ for clinical success, defined as resolution of leukocytosis, fever, and tachypnea. Patients were classified as treatment with TCN or TMP-SMZ based on definitive agent used for ≥50% of the treatment course and ≥4 days. Inclusion criteria were age ≥18 years, confirmed on respiratory culture from January 2013 to November 2020, and appropriate definitive antibiotic dosing. Pregnancy, incarceration, -resistant or intermediate to definitive therapy, and combination therapy for treatment of pneumonia were exclusion criteria. Secondary outcomes were microbiologic success and recurrence or reinfection within 30 days requiring treatment.
Results: A total of 80 patients were included (21 TCN [15 minocycline, 6 doxycycline], 59 TMP-SMZ). There was no difference in clinical success (28.6% vs 25.4%; = 0.994), microbiologic success (n = 28, 55.6% vs 66.4%; = 0.677), or recurrence or reinfection (n = 24, 66.7% vs 26.7%; = 0.092) between TCN and TMP-SMZ, respectively.
Conclusion And Relevance: Clinical and microbiologic success rates were similar in patients treated with TCN compared with TMP-SMZ for pneumonia. These data suggest minocycline and doxycycline may be options to treat pneumonia, but conclusive clinical data continue to be lacking.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/10600280231166413 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunopathogenesis and immunotherapy of diabetes-associated periodontitis.
Clin Oral Investig
January 2025
Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China.
Objectives: This paper aims to review the immunopathogenesis of Diabetes-associated periodontitis (DPD) and to propose a description of the research progress of drugs with potential clinical value from an immunotherapeutic perspective.
Materials And Methods: A comprehensive literature search was conducted in PubMed, MEDLINE, Embase, Web of Science, Scopus and the Cochrane Library. Inclusion criteria were studies on the association between diabetes and periodontitis using the Boolean operator "AND" for association between diabetes and periodontitis, with no time or language restrictions.
RamA upregulates the ATP-binding cassette transporter to mediate resistance to tetracycline-class antibiotics and the stability of membranes in .
Microbiol Spectr
December 2024
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Article Synopsis
- RamA is a crucial regulator in bacteria, enhancing resistance to tetracycline-class antibiotics by activating the operon responsible for multidrug resistance.
- The deletion of RamA leads to significantly reduced transcription levels of this operon, while restoring RamA reinstates normal function.
- The study highlights RamA's role in bacterial membrane stability and suggests potential pathways for developing new antimicrobial treatments against resistant strains.
Discordant Susceptibilities of Enterobacterales to Different Tetracycline Classes.
Cureus
December 2024
Internal Medicine, University of Maryland Medical Center, Baltimore, USA.
When bacteria are tetracycline- or doxycycline-resistant, the ability of these bacteria to be susceptible to the other tetracyclines is not well defined. Consequently, gaining knowledge about the ability to infer Enterobacterales susceptibility to minocycline and third-generation tetracycline antibiotics from surrogates is vital. In this study, we show that tigecycline may be a reasonable surrogate from which clinicians can infer omadacycline and eravacycline susceptibilities, even in the presence of doxycycline and tetracycline resistance.
View Article and Find Full Text PDFBloodstream Infection Combined with Thoracic Infection Caused by : A Case Report and Review of the Literature.
Infect Drug Resist
December 2024
Department of Laboratory Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, People's Republic of China.
Objective: is usually found in urogenital tract infections and is associated with several extra-genitourinary infections, including septic arthritis, bacteremia, and meningitis. Here, we report a rare case of induced bloodstream infection with thoracic inflammation in a surgical patient.
Methods: A 56-year-old male who underwent surgery for multiple pelvic and rib fractures developed fever, pleural effusion, and wound exudation despite receiving prophylactic anti-infection treatment with cefotiam.
Photocatalytic degradation of tetracycline antibiotics and elimination of N-nitrosodimethylamine formation potential by BiOCl/ZnInS heterostructure under visible-light irradiation.
J Environ Manage
December 2024
State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China.
Photocatalysis is an effective method for removing tetracycline antibiotics, which are important precursors to the potential carcinogen N-nitrosodimethylamine (NDMA). Herein, a BiOCl/ZnInS heterojunction was successfully synthesized using a simple hydrothermal method. This heterojunction was applied for the first time to degrade various tetracycline antibiotics and reduce NDMA formation potential (NDMA-FP) under visible-light irradiation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!