A Lewis acid Sc(OTf)-catalyzed annulation reaction of vinyl diazoacetates with formed α,β-unsaturated imines for the preparation of indole-fused tricyclic rings has been reported. This strategy involves a sequential addition/rebound addition process of vinyl diazoacetates and an dedinitrogenation. This annulation protocol features low-cost catalysts, mild reaction conditions, and facilely prepared substrates.
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| http://dx.doi.org/10.1021/acs.orglett.3c00192 | DOI Listing |
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