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Pyoderma Gangrenosum: A Nightmare for Breast Surgery-Two Case Reports.
Eur J Breast Health
January 2025
Department of General Surgery, Gülhane Training and Research Hospital, University of Health Sciences Turkey, Ankara, Turkey.
Article Synopsis
- Pyoderma gangrenosum (PG) is a rare skin condition that causes painful ulcers and is often incorrectly diagnosed as an infection.
- The report discusses two cases of PG following breast surgeries, where both patients initially received ineffective treatment through debridements and antibiotics.
- Effective treatment was achieved using oral doxycycline and topical tacrolimus, highlighting the importance of early diagnosis and proper management to prevent patient suffering and disfigurement.
Postsurgical pyoderma gangrenosum after mastectomy with a familial component.
J Surg Case Rep
October 2024
Division of Surgical Oncology, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, United States.
Postsurgical pyoderma gangrenosum (PSPG) is a rare, ulcerative skin condition that presents a diagnostic challenge due to its similar presentation to infectious etiologies in the postsurgical period-often leading to gratuitous and unnecessary surgery and antibiotic use. We report a 37-year-old female with breast cancer who received neoadjuvant chemotherapy and immunotherapy and underwent bilateral skin-sparing mastectomies who developed delayed bilateral mastectomy skin flap necrosis secondary to PSPG. This case had rare factors associated with the development of PSPG such as preoperative systemic therapy and a familial component.
View Article and Find Full Text PDFPyoderma Gangrenosum in a 75-Year-Old Male With Follicular Diffuse Large B-cell Lymphoma.
Cureus
August 2024
Internal Medicine, East Alabama Medical Center, Opelika, USA.
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that characteristically presents with progressive ulcerative lesions. The association of PG with hematological malignancies remains unclear due to its varied clinical presentation. Herein, we report the unusual case of PG in a 75-year-old male with stage III follicular diffuse large B-cell lymphoma.
View Article and Find Full Text PDFUlcerative erythematous papules and plaques on the face and lower legs of a man living with HIV: a clinicopathological challenge.
Int J Dermatol
November 2024
Department of Dermatology, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Article Synopsis
- * His facial lesions appeared as violaceous plaques, while his lower legs displayed ulcerative lesions with necrosis and purple borders, resembling pyoderma gangrenosum and cutaneous lymphoma.
- * A biopsy and rapid plasma reagin test confirmed the diagnosis of lues maligna, leading to successful treatment with penicillin G benzathine.
Novel Treatment of Pyoderma Gangrenosum With Porcine-Derived Extracellular Matrix Following Bilateral Latissimus Dorsi Breast Reconstruction: A Case Report.
Eplasty
May 2024
Department of Plastic Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Pyoderma gangrenosum (PG) is a rare disease characterized by ulcerative cutaneous lesions that can occur postoperatively and is often associated with autoimmune disorders. PG is diagnosed by excluding other conditions that can cause ulcerations, such as infections, which may also result in immunosuppressive treatment delays and suboptimal wound care. Operative debridement of wounds has traditionally been avoided in the acute setting secondary to pathergy.
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