Natural killer cell epigenetic reprogramming in tumors and potential for cancer immunotherapy.
Epigenomics
Department of Medical Laboratory Sciences, School of Paramedicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Published: February 2023
AI Article Synopsis
- * Tumors can exploit epigenetic changes to evade the immune system, but these modifications can also be targeted to enhance NK cell activation against cancer.
- * The review emphasizes the potential of using knowledge of epigenetic regulation to develop NK cell-based therapies for more effective cancer treatment.
Article Abstract
Natural killer (NK) cells are critical members of the innate lymphoid cell population and have a pivotal role in cancer eradication. NK cell maturation, development and function are tightly regulated by epigenetic modifications, which can also be recruited for cancer propagation and immune escape. NK cells have the potential to be activated against tumors through several epigenetic regulators. Given that epigenetic changes are inducible and reversible, focusing on aberrant epigenetic regulations recruited by tumor cells provides a tremendous opportunity for cancer treatment. This review presents a comprehensive picture of NK cell normal epigenetic regulation and cancer-driven epigenetic modifications. From our perspective, a better understanding of epigenetic regulators that can edit and revise NK cells' activity is a promising avenue for NK cell-based therapy in cancer management.
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| http://dx.doi.org/10.2217/epi-2022-0454 | DOI Listing |
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