A rapid and simple method was developed for the synthesis of diarylmethyl thioethers a DABCO-catalyzed 1,6-conjugate addition reaction of -quinone methides (-QMs) with organosulfur reagents. A series of diarylmethyl thioethers were synthesized at 13-85% yields by this method. After that, the antibacterial activities of synthesized diarylmethyl thioethers and their derivatives were evaluated. The MIC range (μg mL) against ATCC 25923 and clinically isolated methicillin-resistant was 8-128 and 64-128, respectively.
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| http://dx.doi.org/10.1039/d3ra01815f | DOI Listing |
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