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| http://dx.doi.org/10.1093/ehjcr/ytad204 | DOI Listing |
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Neurons with larval synaptic targets pioneer the later nervous system in the annelid .
Front Neurosci
January 2025
Michael Sars Centre, University of Bergen, Bergen, Norway.
Comparative studies on the development of nervous systems have a significant impact on understanding animal nervous system evolution. Nevertheless, an important question is to what degree neuronal structures, which play an important role in early stages, become part of the adult nervous system or are relevant for its formation. This is likely in many direct developers, but it is not the case in forms with catastrophic metamorphosis.
View Article and Find Full Text PDFDual role of Xenopus Odf2 in multiciliated cell patterning and differentiation.
Dev Biol
January 2025
Aix Marseille Univ, CNRS, IBDM, Turing Centre for Living Systems, Marseille, France. Electronic address:
In developing tissues, the number, position, and differentiation of cells must be coordinately controlled to ensure the emergence of physiological function. The epidermis of the Xenopus embryo contains thousands of uniformly distributed multiciliated cells (MCCs), which grow hundreds of coordinately polarized cilia that beat vigorously to generate superficial water flow. Using this model, we uncovered a dual role for the conserved centriolar component Odf2, in MCC apical organization at the cell level, and in MCC spatial distribution at the tissue level.
View Article and Find Full Text PDFAhASRK1, a peanut dual-specificity kinase that activates the Ca-ROS-MAPK signalling cascade to mediate programmed cell death induced by aluminium toxicity via ABA.
Plant Physiol Biochem
January 2025
Guangxi Key Laboratory for Agro-Environment and Agro-Product Safety, College of Agriculture, GuangXi University, Nanning, 530004, China; National Demonstration Center for Experimental Plant Science Education/College of Agriculture, Nanning, 530004, China; Guangxi University Key Laboratory of Crop Cultivation and Tillage, Nanning, 530004, China. Electronic address:
Aluminium (Al)-induced programmed cell death (PCD) is thought to be a main cause of Al phytotoxicity. However, the underlying mechanism by which Al induces PCD in plants is unclear. In this study, we characterized the function of AhASRK1 (Aluminum Sensitive Receptor-like protein Kinase1), an Al-induced LRR-type receptor-like kinase gene.
View Article and Find Full Text PDFProximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics.
Sci Rep
January 2025
U1248 Pharmacology & Transplantation, Inserm, Univ. Limoges, Limoges, France.
Deciphering the sources of variability in drug responses requires to understand the processes modulating drug pharmacokinetics. However, pharmacological research suffers from poor reproducibility across clinical, animal, and experimental models. Predictivity can be improved by using Organs-on-Chips, which are more physiological, human-oriented, micro-engineered devices that include microfluidics.
View Article and Find Full Text PDFEffect of ultrasonically-activated irrigation protocols used for regenerative endodontics on removal of dual species biofilm in a three-dimensionally printed tooth model: in vitro study.
BMC Oral Health
January 2025
Endodontics, Conservative Dentistry Department, Faculty of Dentistry, Alexandria University, 13 Champolion St, Azarita, Alexandria, Egypt.
Introduction: Eradication of residual biofilm from root canal dentine is critical for the success of regenerative endodontic procedures (REPs).
The Aim Of The Study: To evaluate the influence of ultrasonically activated irrigants in concentrations used for REPs for removal of dual-species biofilm from three-dimensionally printed tooth models with attached dentine samples.
Methodology: Seventy-two three-dimensionally printed teeth models were fabricated with a standardized slot in the apical third of the root to ensure a precise fit with a human root dentine specimen.
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