AI Article Synopsis
- High-grade serous ovarian carcinoma (HGSOC) is a really serious type of cancer that affects women and is hard to prevent.
- Researchers found that a hormone called progesterone can help stop this cancer from happening and spreading.
- The study showed that progesterone works better in certain models and may encourage cancer cells to die, showing promise for using it as a way to prevent this disease.
Article Abstract
High-grade serous ovarian carcinoma (HGSOC) is one of the most fatal gynecological cancers and has no effective prevention strategies. Herein, we demonstrated that progesterone significantly inhibited the occurrence, metastasis, and ascites of ovarian cancer , and the tumor inhibition effect of progesterone was in the tubo-ovarian intrabursal model than in the intraperitoneal or subcutaneous models. Further data demonstrated that progesterone-treated fallopian tube fibroblasts conditioned medium significantly inhibit HGSOC precancerous cell viability by inducing pyroptosis via the IL-6/ROS/NLRP3/GSDMD pathway, implying that the oviduct microenvironment may enhance progesterone's protective effects on ovarian cancer. This study elucidated progesterone inhibiting ovarian cancer mechanism and provided evidence for progesterone as a chemo-preventive role for HGSOC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130919 | PMC |
| http://dx.doi.org/10.1016/j.isci.2023.106523 | DOI Listing |
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