is an annual herbaceous plant widely cultivated for oil production in China, Japan, and Korea. In this study, we investigated the effect of perilla oil (PO) on thrombosis induced by collagen and epinephrine (CE) in rats. The oral administration of PO significantly increased prothrombin time (PT) and activated partial thromboplastin time (aPTT) in the blood plasma and inhibited the expression of cells adhesion markers (CAMs) such as intercellular CAM-1 (ICAM-1), vascular CAM (VCAM-1), E-selectin and P-selectin in the aorta tissue. Furthermore, pulmonary occlusion induced by CE in rats was suppressed by PO. α-Linolenic acid (ALA) was quantified at 60.14 ± 2.50 g/100 g of PO, and its oral administration at the same concentration with that in PO exerted the similar effect on PT, aPTT, ICAM-1, VCAM-1, E-selectin and P-selectin in CE-induced thrombosis rats. Taken together, PO and ALA significantly ameliorated thrombosis by regulating CAMs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130252 | PMC |
| http://dx.doi.org/10.1007/s10068-022-01241-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Variation of nanoparticles in pickering emulsion optimize the physical, control-release and sustained antioxidant properties of hydroxypropyl methylcellulose based microporous film.
Int J Biol Macromol
December 2024
School of Food Science and Engineering, Yangzhou University, Huayang Xilu 196, Yangzhou, Jiangsu 225127, People's Republic of China.
The proper encapsulation of liposoluble tea polyphenols (LTP) is expected to better protect oil system. Chitosan hydrochloride-carboxymethyl starch (CHC-CMS) nanoparticles-based Pickering emulsions and hydroxypropyl methylcellulose/sodium citrate (HPMC/SC) microporous film were combined to embed and control-release LTP. With the CHC:CMS ratio varied from 1:0.
View Article and Find Full Text PDFCold-pressed extraction of perilla seed oil enriched with alpha-linolenic acid mitigates tumour progression and restores gut microbial homeostasis in the AOM/DSS mice model of colitis-associated colorectal cancer.
PLoS One
December 2024
Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
The present investigation explores into the influence of dietary nutrients, particularly alpha-linolenic acid (ALA), a plant-derived omega-3 fatty acid abundant in perilla seed oil (PSO), on the development of colitis-associated colorectal cancer (CRC). The study employs a mouse model to scrutinize the effects of ALA-rich PSO in the context of inflammation-driven CRC. Perilla seeds were subjected to oil extraction, and the nutritional composition of the obtained oil was analysed.
View Article and Find Full Text PDFPerilla Seed Oil and Protein: Composition, Health Benefits, and Potential Applications in Functional Foods.
Molecules
November 2024
Heilongjiang Province Key Laboratory of Food Processing, Harbin 150086, China.
Perilla () seeds are emerging as a valuable resource for functional foods and medicines owing to their rich oil and protein content with diverse nutritional and health benefits. Perilla seed oil (PSO) possesses a high level of a-linolenic acid (ALA), a favorable ratio of unsaturated to saturated fatty acids, and other active ingredients such as tocopherols and phytosterols, which contribute to its antioxidant, anti-inflammatory, and cardiovascular protective effects. The balanced amino acid ratio and good functional properties of perilla seed protein make it suitable for a variety of food applications.
View Article and Find Full Text PDFPerilla Seed Oil: A Review of Health Effects, Encapsulation Strategies and Applications in Food.
Foods
November 2024
Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Wuhan 430062, China.
Perilla ( L.) is an annual herbaceous plant whose seed oil is rich in unsaturated fatty acids such as alpha-linolenic acid (ALA). This oil exhibits various health benefits, including antioxidant, anti-inflammatory, lipid-lowering, hypoglycemic, neuroprotective and immunomodulatory activities.
View Article and Find Full Text PDFCold-pressed perilla seed oil: Investigating its protective influence on the gut-brain axis in mice with rotenone-induced Parkinson's disease.
Food Sci Nutr
September 2024
Institute of Nutrition, Mahidol University Nakhon Pathom Thailand.
Article Synopsis
- Perilla seed oil, rich in alpha-linolenic acid (ALA), is studied for its potential health benefits, especially regarding neurodegenerative diseases and inflammation.
- In an experiment with male C57BL/6 mice, different doses of perilla seed oil were administered alongside a fish oil diet to observe effects on Parkinson's disease induced by rotenone.
- High doses of perilla oil led to significant health improvements, including reduced inflammation and neurodegeneration, as well as enhanced gut microbiota diversity, indicating its promise for treating intestinal and neurological issues related to Parkinson’s disease.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!