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Advances in basic and translational research in atrial fibrillation. | LitMetric

AI Article Synopsis

  • * Despite advancements, the precise molecular and cellular processes behind AF remain unclear, and existing treatments, including antiarrhythmic drugs and ablation, often come with significant drawbacks and limitations, particularly for persistent AF cases.
  • * The review highlights recent progress in understanding AF's epidemiology, genetics, and treatment options, focusing on current and potential therapies and innovative approaches to AF management.

Article Abstract

Atrial fibrillation (AF) is a very common cardiac arrhythmia with an estimated prevalence of 33.5 million patients globally. It is associated with an increased risk of death, stroke and peripheral embolism. Although genetic studies have identified a growing number of genes associated with AF, the definitive impact of these genetic findings is yet to be established. Several mechanisms, including electrical, structural and neural remodelling of atrial tissue, have been proposed to contribute to the development of AF. Despite over a century of exploration, the molecular and cellular mechanisms underlying AF have not been fully established. Current antiarrhythmic drugs are associated with a significant rate of adverse events and management of AF using ablation is not optimal, especially in cases of persistent AF. This review discusses recent advances in our understanding and management of AF, including new concepts of epidemiology, genetics and pathophysiological mechanisms. We review the current status of antiarrhythmic drug therapy for AF, new potential agents, as well as mechanism-based AF ablation. This article is part of the theme issue 'The heartbeat: its molecular basis and physiological mechanisms'.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150218PMC
http://dx.doi.org/10.1098/rstb.2022.0174DOI Listing

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