AI Article Synopsis
- Global population aging is causing neurodegenerative diseases (NDs), like Alzheimer's and Parkinson's, to rapidly increase as leading causes of death, posing serious health risks.
- The exact causes of NDs are not fully understood but may involve factors like immune responses, oxidative stress, and protein aggregation; gut microbiota is thought to affect brain function and emotional health.
- Bile acids are gaining attention for their potential neuroprotective properties and role in the gut-brain connection, warranting further investigation to understand their impact on NDs and explore prevention and treatment options.
Article Abstract
With the acceleration of global population aging, neurodegenerative diseases (NDs) will become the second leading cause of death in the world, which seriously threatens human life and health. Alzheimer's disease and Parkinson's disease are the most common and typical NDs. The exact mechanisms of the NDs occurrence and development remain unclear, which may be related to immune, oxidative stress, and abnormal aggregation of pathogenic proteins. Studies have suggested that gut microbiota (GM) influences brain function and plays an important role in regulating emotional and cognitive function. Recently, bile acids (BAs) have become the "star molecule" in the microbiota-gut-brain (MGB) axis research. BAs have been reported to exert anti-inflammatory, antioxidant, and neuroprotective activities in NDs. However, the role of BAs in the connection between GM and the central nervous system (CNS) is still unclear. In this review, we will review the possible mechanisms of BAs between GM and NDs and explore the function of BAs to provide ideas for the prevention and treatment of NDs in the future.
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| http://dx.doi.org/10.1007/s12035-023-03340-9 | DOI Listing |
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