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Neurologic adverse events associated with BRAF and MEK inhibitor therapy in patients with malignant melanoma: a disproportionality analysis using the Food and Drug Administration Adverse Event Reporting System.
Melanoma Res
December 2024
Department of Dermatology, University of Arizona College of Medicine - Tucson, Tucson, Arizona, USA.
BRAF and MEK inhibitor (BRAFi + MEKi) therapy has improved the treatment of solid tumors with BRAF mutation. However, their neurologic adverse events (nAEs) have been largely unexplored. This study aimed to provide clinicians with more updated knowledge on nAEs associated with BRAFi + MEKi therapy in patients with malignant melanoma compared with nonmelanoma cancers.
View Article and Find Full Text PDFFACTFINDERS for PATIENT SAFETY: Preventing procedure-related complications: Epidural lipomatosis and postpartum steroid exposure.
Interv Pain Med
June 2024
Emory University, Department of Orthopaedics, Atlanta, GA, USA.
This series of FactFinders presents a brief summary of the evidence and outlines recommendations to improve our understanding and management of potential procedure-related complications. Evidence in support of the following facts is presented. (1) -- There is low-level evidence of an association between epidural steroid injections (ESIs) and the development and/or worsening of spinal epidural lipomatosis (SEL).
View Article and Find Full Text PDFLumbar Epidural Corticosteroid Injection-Induced Epidural Lipomatosis.
J Clin Rheumatol
October 2024
Department of Radiology, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Management of Pediatric Patient with Multiple Cranial, Intracranial, and Spinal Manifestations of Penttinen Syndrome: A Case Report.
Pediatr Neurosurg
October 2024
Division of Neurosurgery, Children's Hospital Colorado, Aurora, Colorado, USA.
Introduction: Penttinen premature aging syndrome is caused by mutations in the PDGFRB gene. We describe the case of a 10-year-old girl with a de novo c.1994T>C variant in PDGFRB who developed multiple cranial, intracranial, and spinal manifestations, including macrocephaly, enlarged convexity subarachnoid spaces crossed by numerous vascularized arachnoid trabecule, hydrocephalus, spinal epidural lipomatosis, a low conus medullaris, calvarial thinning with large anterior fontanelle, and a skull fracture with bilateral epidural hematomas.
View Article and Find Full Text PDFArthroscopic-assisted uni-portal spinal surgery combined with modified unilateral laminotomy with bilateral decompression for the treatment of lumber epidural lipomatosis: Case report and new therapeutic method.
J Orthop
December 2024
Department of Sports Medicine, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.
Background: Lumbar spinal epidural lipomatosis (SEL) is a rare condition characterized by the pathological proliferation of adipose tissue in the epidural space of the spinal canal. This study presents the case of a 59-year-old male with lumbar SEL treated effectively in the short term through arthroscopic-assisted uniportal spinal surgery (AUSS) combined with a modified circle-drawing unilateral laminotomy with bilateral decompression (ULBD) technique.
Methods: A modified circle-drawing ULBD procedure was executed via AUSS for a patient with SEL.
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