Introduction And Importance: Primary angiosarcoma of breast (PAB) is a rare and aggressive malignancy with limited published literature. This article aims to disclose the diagnosis and treatment of this case, review previous case reports, and provide clinical experience to breast surgeons.
Case Presentation: A 36-year-old Asian female presented with a diffuse mass growing rapidly in her left breast. The ultrasonography (USG) suspected granulomatous mastitis. The core needle biopsy (CNB) confirmed the diagnosis of breast angiosarcoma (AS). She underwent mastectomy without axillary lymph node dissection (ALND) followed by adjuvant chemotherapy. About 11 months after mastectomy, the patient had bone metastasis.
Clinical Discussion: PAB is a rare vascular neoplasia, characterized by aggressive patterns, poor prognosis, and high malignant potential. It is difficult to diagnose or differentiate only by clinical or imaging examination. Biopsy and immunohistochemical staining are the most reliable method. Mastectomy is the most common treatment.
Conclusion: PAB is a rare and malignant cancer. We should pay attention to the diffuse progressive masses in the breast of young female, and perform MRI and biopsy if necessary. Mastectomy is the only treatment known that has proven to benefit these patients. There are no evidence-based guidelines regarding treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10173155 | PMC |
| http://dx.doi.org/10.1016/j.ijscr.2023.108219 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An and efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs.
Mol Ther Methods Clin Dev
December 2024
SwanBio Therapeutics, Inc., Philadelphia, PA, USA.
Adrenomyeloneuropathy is a progressive neurodegenerative disease caused by pathogenic variants in the gene, resulting in very-long-chain fatty acid (VLCFA) accumulation that leads to dying-back axonopathy. Our candidate gene therapy, SBT101 (AAV9-human [h]), aims to ameliorate pathology by delivering functional copies of h to the spinal cord. Transduced cells produce functional ABCD1 protein, thereby repairing the underlying biochemical defect.
View Article and Find Full Text PDFPulmonary root remodeling procedure for symptomatic supravalvular pulmonary stenosis in an adult patient who underwent pulmonary artery banding: a case report.
BMC Cardiovasc Disord
November 2024
Cardiovascular Surgery Department, Sapporo Medical University, S-1, W-16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Background: Pulmonary artery banding (PAB) is performed as a palliative surgery for congenital heart diseases. Although pulmonary stenosis is one of the complications of PAB, symptomatic supravalvular pulmonary stenosis (SVPS) in adulthood after PAB is an extremely rare condition. Further, very few studies have focused on surgical cases of SVPS in adult.
View Article and Find Full Text PDFAn Integrated Module Performs Selective 'Online' Epoxidation in the Biosynthesis of the Antibiotic Mupirocin.
Angew Chem Int Ed Engl
December 2024
School of Chemistry, University of Bristol, BS8 1TS, Bristol, UK.
The delineation of the complex biosynthesis of the potent antibiotic mupirocin, which consists of a mixture of pseudomonic acids (PAs) isolated from Pseudomonas fluorescens NCIMB 10586, presents significant challenges, and the timing and mechanisms of several key transformations remain elusive. Particularly intriguing are the steps that process the linear backbone from the initial polyketide assembly phase to generate the first cyclic intermediate PA-B. These include epoxidation as well as incorporation of the tetrahydropyran (THP) ring and fatty acid side chain required for biological activity.
View Article and Find Full Text PDFTotal pelvic exenteration extended to pelvic bones with subsequent VRAM flap reconstruction in patient with recurrent anal squamous cell carcinoma following chemoradiotherapy.
BMJ Case Rep
July 2024
Coloproctology Unit, Hospital Politécnico y Universitario La Fe, Valencia, Spain.
Anal squamous cell carcinoma, typically associated with human papillomavirus infection, remains a rare malignancy. This article outlines a case of local recurrence in a male patient with a history of HIV and hepatitis C virus infection, previously treated with chemoradiotherapy. Extensive tumour involvement called for total pelvic exenteration extended to anterior osteomuscular compartment and genitalia.
View Article and Find Full Text PDFPrimary Angiosarcoma of Breast: a Case Series of Rare Disease.
Indian J Surg Oncol
March 2024
Department of Surgical Oncology, Kottayam Medical College, 3Rd Floor Casualty Building, Medical College, Kottayam, Kerala State India.
Primary angiosarcoma of breast (PAB) is a very rare disease and it accounts for only 0.05% of all malignant breast tumors. We present the clinical radiological and pathological features, treatment given, and outcome of this rare disease in our institute in a period of 5 years, aiming at contributing to the knowledge of prognostic factors of this rare disease.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!