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Precision sampling of discrete sites identified during in-vivo functional testing in the mammalian heart.
Commun Eng
November 2024
KU Leuven, Department of Cardiovascular Sciences, Cardiovascular Imaging and Dynamics, Leuven, Belgium.
Ventricular arrhythmias after myocardial infarction (MI) originate from discrete areas within the MI border zone (BZ), identified during functional electrophysiology tests. Accurate sampling of arrhythmogenic sites for ex-vivo study remains challenging, yet is critical to identify their tissue, cellular and molecular signature. In this study, we developed, validated, and applied a targeted sampling methodology based on individualized 3D prints of the human-sized pig heart.
View Article and Find Full Text PDFElectric Field-Based Spatial Analysis of Noncontact Unipolar Electrograms to Map Regional Activation-Repolarization Intervals.
JACC Clin Electrophysiol
August 2023
Department of Cardiovascular Sciences, Cardiovascular Imaging and Dynamics, KU Leuven, Leuven, Belgium. Electronic address:
Background: Spatial heterogeneity in repolarization plays an important role in generating and sustaining cardiac arrhythmias. Reliable determination of repolarization times remains challenging.
Objectives: The goal of this study was to improve processing of densely sampled noncontact unipolar electrograms to yield reliable high-resolution activation and repolarization maps.
Regional beat-to-beat variability of repolarization increases during ischemia and predicts imminent arrhythmias in a pig model of myocardial infarction.
Am J Physiol Heart Circ Physiol
July 2023
Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Ventricular arrhythmia (VT/VF) can complicate acute myocardial ischemia (AMI). Regional instability of repolarization during AMI contributes to the substrate for VT/VF. Beat-to-beat variability of repolarization (BVR), a measure of repolarization lability increases during AMI.
View Article and Find Full Text PDFHeterogeneity of Repolarization and Cell-Cell Variability of Cardiomyocyte Remodeling Within the Myocardial Infarction Border Zone Contribute to Arrhythmia Susceptibility.
Circ Arrhythm Electrophysiol
May 2023
Department of Cardiovascular Sciences, Experimental Cardiology (M.A., S.E.-T., R.D.P., G.G., M.Y., R.W., H.L.R., K.R.S.), KU Leuven, Belgium.
Background: After myocardial infarction, the infarct border zone (BZ) is the dominant source of life-threatening arrhythmias, where fibrosis and abnormal repolarization create a substrate for reentry. We examined whether repolarization abnormalities are heterogeneous within the BZ in vivo and could be related to heterogeneous cardiomyocyte remodeling.
Methods: Myocardial infarction was induced in domestic pigs by 120-minute ischemia followed by reperfusion.
InsPR-RyR channel crosstalk augments sarcoplasmic reticulum Ca release and arrhythmogenic activity in post-MI pig cardiomyocytes.
J Mol Cell Cardiol
June 2023
KU Leuven, Department of Cardiovascular Sciences, Laboratory of Experimental Cardiology, 3000 Leuven, Belgium. Electronic address:
Article Synopsis
- The heart's muscle cells (cardiomyocytes) need calcium (Ca) for their contractions, and these cells rely on a balanced interaction between different calcium channels to work properly.
- In heart diseases, this interaction can get messed up, leading to less calcium release and irregular heartbeats (arrhythmias).
- New research has found that a specific calcium release pathway (InsPR) can cause problems in heart cells, especially around areas damaged by heart attacks, which can worsen heart rhythm issues.
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