The present work presents a methodology for modeling the quality of surface water, aiming at the management of hydrographic basins and the best allocation of resources in the treatment of sanitary sewage, considering the predominant uses of water and microbiological quality. The QUAL-UFMG model was used, composed of Excel spreadsheets, where visual basic for applications (VBA) routines were implemented, enabling deterministic and probabilistic modeling through Monte Carlo simulations. The proposed methodology was applied to a Brazilian hydrographic basin, called the GD2 Planning Unit (Grande River Slopes), considering the discharges of sanitary sewage from 30 municipal seats and approximately 740,000 inhabitants. Four scenarios were studied: the current situation (C-01), the trend for the year 2033 (C-02), compliance with environmental legislation (C-03) and compliance with the main uses of the basin (C-04). The results showed that for C-01 and C-02, the water quality, in terms of thermotolerant coliforms, in most stretches does not meet the defined uses. Even complying with the provisions of environmental legislation (C-03), which do not provide for disinfection, only the largest watercourses would have adequate quality for use. Complete service would only be achieved in C-04, which provides for universal sewage treatment with disinfection for the vast majority of municipalities.
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http://dx.doi.org/10.2166/wst.2023.117 | DOI Listing |
Geotech Geol Eng (Dordr)
January 2025
School of Mechanical, Aerospace and Civil Engineering, The University of Sheffield, Sheffield, UK.
Earthquake induced soil liquefaction poses a significant threat to buildings and infrastructure, as evidenced by numerous catastrophic seismic events. Existing approaches of regional liquefaction hazard assessment predominantly rely on deterministic analysis methods. This paper presents a novel Probabilistic Liquefaction Hazard Analysis (PLHA) framework based on Monte-Carlo (MC) simulations to mitigate future seismic risks associated with liquefaction.
View Article and Find Full Text PDFNat Mater
January 2025
State Key Laboratory of Surface Physics, Key Laboratory of Micro and Nano Photonic Structures (MOE), and Department of Physics, Fudan University, Shanghai, China.
Polymorphism, commonly denoting diverse molecular or crystal structures, is crucial in the natural sciences. In van der Waals antiferromagnets, a new type of magnetic polymorphism arises, presenting multiple layer-selective magnetic structures with identical total magnetization. However, resolving and manipulating such magnetic polymorphs remain challenging.
View Article and Find Full Text PDFInt J Clin Pharm
January 2025
Center for Health Policy and Technology Evaluation, Peking University Health Science Center, Beijing, 100191, China.
Background: Lung cancer is the leading cause of cancer-related deaths in China, and pembrolizumab shows differential efficacy in advanced non-small cell lung cancer (NSCLC) with different PD-L1 expression levels.
Aim: To assess the cost-effectiveness of PD-L1 testing associated with pembrolizumab for first-line treatment of NSCLC from the perspective of Chinese healthcare system.
Method: Over a lifetime horizon, a three-state partitioned survival model was developed to assess the cost-effectiveness of PD-L1 testing and no PD-L1 testing.
BMJ Open
January 2025
Institute of Health Economics and Clinical Epidemiology, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany
Background: Magnetic resonance-guided transurethral ultrasound ablation (MR-TULSA) is a new focal therapy for treating localised prostate cancer that is associated with fewer adverse effects (AEs) compared with established treatments. To support large-scale clinical implementation, information about cost-effectiveness is required.
Objective: To evaluate the cost-utility of MR-TULSA compared with robot-assisted radical prostatectomy (RARP), external beam radiation therapy (EBRT) and active surveillance (AS) for patients with low- to favourable intermediate-risk localised prostate cancer.
J Hazard Mater
January 2025
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Understanding the negative effects of agrochemicals on the environment and human health is indispensable for achieving green agriculture. In this study, the optimized UHPLC-MS/MS method achieved a highly sensitive quantification of tolfenpyrad in cabbage within 4.04 min.
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