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Development and growth of cavernosal sinusoidal endothelia in the external genitalia of human fetuses.
Ann Anat
December 2024
Department of Urology, Graduate School of Medicine and Dentistry, Hiroshima University School of Medicine, Hiroshima, Japan.
Background: There is little information about when and how cavernosal sinusoidal endothelia develop in the external genitalia of fetuses.
Methods: We examined histological sections of erectile tissue in 37 human fetuses (25 males and 12 females) whose gestational age (GA) ranged from 8 to 40 weeks.
Results: The sinusoidal lumen was filled with blood in the glans of the penis and clitoris at a GA of 10 to 11 weeks, and in the corpus spongiosum at a GA of 15 to 16 weeks.
Dual-Stage Cross-Flow Filtration: Integrated Capture and Purification of Virus-Like Particles.
Biotechnol Bioeng
December 2024
Institute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Virus-like particles (VLPs) are a versatile technology for the targeted delivery of genetic material through packaging and potential surface modifications for directed delivery or immunological issues. Although VLP production is relatively simple as they can be recombinantly produced using microorganisms such as Escherichia coli, their current downstream processing often relies on individually developed purification strategies. Integrating size-selective separation techniques may allow standardized platform processing across VLP purification.
View Article and Find Full Text PDFExpandable Transvalvular Flow Pumps: "It's the Flow, Dummy".
JACC Cardiovasc Interv
December 2024
Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Health, Detroit, Michigan, USA. Electronic address:
Fully 4D-Printed Near-Infrared-Actuated Lab-on-Valve Solid-Phase Extraction Devices.
Anal Chem
December 2024
Department of Chemistry, National Chung Hsing University, Taichung City 402202, Taiwan, ROC.
Four-dimensional printing (4DP) technologies can expand the functionality of stimuli-responsive devices to enable the integration of multiple stimuli-responsive parts into a compact device. Herein, we used digital light processing three-dimensional printing technique, flexible photocurable resins, and photocurable resins of the temperature-responsive hydrogels comprising -isopropylacrylamide (NIPAM), ,'-methylenebis(acrylamide) (MBA), and graphene for 4DP of a lab-on-valve (LOV) solid-phase extraction (SPE) device. This device featured flow manifolds and a monolithic packing connected by four near-infrared (NIR)-actuated temperature-responsive switching valves composed of a poly(NIPAM/MBA) (PNM) ball pushing a flexible membrane.
View Article and Find Full Text PDFDifferentiating reactive and neoplastic gamma-delta (γδ) T-cell expansions in the peripheral blood and bone marrow.
Cytometry B Clin Cytom
December 2024
Department of Pathology, Northwestern University Feinberg School of Medicine & Northwestern Memorial Hospital, Chicago, Illinois, USA.
The clinical and immunophenotypic attributes of reactive γδ T-cell expansions are less well characterized than their malignant counterparts, which can pose diagnostic challenges. This study aims to investigate the characteristics and long-term clinical outcomes of reactive γδ T-cell expansions. A retrospective review was performed to identify patients with expanded γδ T-cell population (>15% of T-cells) by flow cytometry in peripheral blood and/or bone marrow specimens over a 17-year period.
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