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Biodegradable fishing gears: A potential solution to ghost fishing and marine plastic pollution.
Mar Pollut Bull
January 2025
UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Fishing gears are conventionally made from non-biodegradable materials including polyamide (PA). When lost in the ocean, these gears have long-lasting impacts, including marine littering, microplastics production, leaching of chemicals, and an extended period of ghost fishing due to its durability. The use of biodegradable co-polyester material such as polybutylene succinate co-adipate-co-terephthalate (PBSAT) and polybutylene succinate-co-butylene adipate (PBSA) as fishing gear materials have been considered as a potential solution to reduce the associated impact.
View Article and Find Full Text PDFEnhancing immunity during ageing by targeting interactions within the tissue environment.
Nat Rev Drug Discov
January 2025
Division of Medicine, University College London, London, UK.
Immunity declines with age. This results in a higher risk of age-related diseases, diminished ability to respond to new infections and reduced response to vaccines. The causes of this immune dysfunction are cellular senescence, which occurs in both lymphoid and non-lymphoid tissue, and chronic, low-grade inflammation known as 'inflammageing'.
View Article and Find Full Text PDFThe urinary eccDNA landscape in prostate cancer reveals associations with genome instability and vital roles in cancer progression.
J Adv Res
January 2025
Department of Urology, Center for Regeneration and Aging, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu 322000 China. Electronic address:
Introduction: Extrachromosomal circular DNA (eccDNA) plays significant roles in cancer progression and prognosis. However, it remains unclear whether cell-free eccDNA, considered more stable than linear DNA, possesses cancer-specific genomic features. Furthermore, the biogenesis and function of eccDNAs are not yet fully understood.
View Article and Find Full Text PDFMangiferin Protects Mesenchymal Stem Cells Against DNA Damage and Cellular Aging via SIRT1 Activation.
Mech Ageing Dev
January 2025
Department of Biological Science, College of Natural Science, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea; BK21 FOUR Education Research Group for Age-Associated Disorder Control Technology, Department of Integrative Biological Science, Chosun University, Gwangju 61452, Republic of Korea; The Basic Science Institute of Chosun University, Chosun University, Gwangju 61452, Republic of Korea. Electronic address:
The protective effects of mangiferin (MAG) against etoposide- and high glucose (HG)-induced DNA damage and aging were investigated in human bone marrow-mesenchymal stem cells (hBM-MSCs). Etoposide, a topoisomerase II inhibitor, was used to induce double-strand breaks (DSBs) in hBM-MSCs, resulting in increased genotoxicity, elevated levels of the DNA damage sensor ATM and CDKN1A, and decreased levels of the aging markers H3 and H4. MAG activated AMPK and SIRT1, thus protecting against DSB-induced damage.
View Article and Find Full Text PDFRECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining.
Exp Mol Med
January 2025
Section on DNA Repair, Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
RecQ helicases, highly conserved proteins with pivotal roles in DNA replication, DNA repair and homologous recombination, are crucial for maintaining genomic integrity. Mutations in RECQL4 have been associated with various human diseases, including Rothmund-Thomson syndrome. RECQL4 is involved in regulating major DNA repair pathways, such as homologous recombination and nonhomologous end joining (NHEJ).
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