Interrupted reactions in chemical synthesis.

Interrupted reactions reroute established processes to new and often unanticipated end points. Of particular interest are the cases in which a known reactive intermediate takes on a new reaction pathway, either because this pathway is lower in energy or because the conventional pathway is no longer available. Through analysis of documented cases, we aim to dissect the known interrupted reactions and trace their mechanistic origins. As new chemical processes are being discovered at a seemingly ever-increasing pace, it is likely that new interrupted reactions will continue to emerge. Our hope is that the cases considered in this Review will help identify new classes of these fascinating transformations.