AI Article Synopsis
- CSF amyloid-β peptide levels and tau phosphorylation are key biomarkers for Alzheimer's disease (AD), with a focus on p-tau181.
- A study analyzed various tau species and found that CSF pT217/T217 was a better predictor for brain amyloid presence via PET scans compared to traditional Aβ biomarkers.
- In individuals showing amyloid positivity, pT217/T217 was more strongly linked to amyloid levels, and in patients with AD symptoms, pT217/T217 and pT205/T205 showed better correlation with tau PET measures than p-tau181.
Article Abstract
Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of Alzheimer's disease (AD). The present study used mass spectrometry to measure concentrations of nine phosphorylated and five nonphosphorylated tau species and phosphorylation occupancies (percentage phosphorylated/nonphosphorylated) at ten sites. In the present study we show that, in 750 individuals with a median age of 71.2 years, CSF pT217/T217 predicted the presence of brain amyloid by positron emission tomography (PET) slightly better than Aβ42/Aβ40 (P = 0.02). Furthermore, for individuals with positive brain amyloid by PET (n = 263), CSF pT217/T217 was more strongly correlated with the amount of amyloid (Spearman's ρ = 0.69) than Aβ42/Aβ40 (ρ = -0.42, P < 0.0001). In two independent cohorts of participants with symptoms of AD dementia (n = 55 and n = 90), CSF pT217/T217 and pT205/T205 were better correlated with tau PET measures than CSF p-tau181 concentration. These findings suggest that CSF pT217/T217 and pT205/T205 represent improved CSF biomarkers of amyloid and tau pathology in AD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154225 | PMC |
| http://dx.doi.org/10.1038/s43587-023-00380-7 | DOI Listing |
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