AI Article Synopsis
- - The gut microbiota plays a crucial role in regulating immunity and brain health, and changes in this microbiota due to aging are associated with health declines in older adults.
- - Researchers performed fecal microbiota transplants from young and old mice to older recipient mice, finding that young microbiota reversed age-related immune and metabolic changes in these older mice.
- - The study suggests that young microbiota can improve cognitive function in aged mice, indicating that targeting the microbiome could be a potential strategy for promoting healthy aging.
Article Abstract
The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3-4 months) or old (19-20 months) donor mice into aged recipient mice (19-20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s43587-021-00093-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!