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Multicomponent Synthesis of Alkyl BCP-Heteroaryls via Electron Donor-Acceptor Complex Photoactivation under Mild Conditions.
J Org Chem
January 2025
College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China.
In the vanguard of sustainable chemistry, the pursuit of efficient pathways for the synthesis of alkyl bicyclo[1.1.1]pentane-heteroaryls has captured the attention of the scientific vanguard.
View Article and Find Full Text PDFTailoring industrial enzymes for thermostability and activity evolution by the machine learning-based iCASE strategy.
Nat Commun
January 2025
Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, PR China.
The pursuit of obtaining enzymes with high activity and stability remains a grail in enzyme evolution due to the stability-activity trade-off. Here, we develop an isothermal compressibility-assisted dynamic squeezing index perturbation engineering (iCASE) strategy to construct hierarchical modular networks for enzymes of varying complexity. Molecular mechanism analysis elucidates that the peak of adaptive evolution is reached through a structural response mechanism among variants.
View Article and Find Full Text PDFPostcolonial technoscience revisited.
Soc Stud Sci
December 2024
Center for the Humanities, Wesleyan University, Middletown, CT, USA.
What does a postcolonial inquiry into technoscience do? And what is it for? I develop these questions by reconsidering one powerful idea: that science and technology studies (STS) is postcolonial when it elucidates the hybridity, heterogeneity, and indeterminacy of global technoscientific formations, and does so to falsify colonial fantasies of hegemony expressed in imperious conceptual generalities and sovereign universalisms. Revisiting Warwick Anderson's expositions of postcolonial STS-initiated in this journal two decades ago-I reflect on the form and force of this critical operation. Despite an animating aversion to universalisms, the pursuit of hybridity and heterogeneity may ultimately universalize a liberal metaphysics of agency.
View Article and Find Full Text PDFA Highly Selective Ammonia Ratiometric Fluorescence Sensor Based on Multifunctional Metal-Organic Framework Platform with Rich Brønsted Acidic Metal Clusters.
Anal Chem
December 2024
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.
Ammonia is a critical chemical in industry and our daily life, but its corrosiveness and toxicity also require enough attention. With the increasing pursuit of beauty, the safety of cosmetics has aroused widespread concern. Aqueous ammonia has been widely used as a universal additive in cosmetics, especially in different types of hair dye products.
View Article and Find Full Text PDFVaccine efficacy induced by 2020-2021 seasonal influenza-derived H3N1 virus-like particles co-expressing M2e5x or N2.
Vaccine
January 2025
Department of Medical Zoology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea; Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address:
Influenza A matrix protein 2 (M2e) and neuraminidase (NA) antigens are known to play important roles in mounting a broad range of protection. Nonetheless, the protective efficacy of the VLP vaccines co-expressing both M2e and NA antigens has not been explored. In this study, we generated 2020/2021 seasonal influenza H3N1 VLPs that co-expressed either M2e5x (H3N1M2e5x) or N2 (H3N1N2 VLP) antigens.
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